Ana C deCarvalho
Overview
Explore the profile of Ana C deCarvalho including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
2242
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Recent Articles
11.
Nagaraja T, deCarvalho A, Brown S, Griffith B, Farmer K, Irtenkauf S, et al.
Cancer Treat Res Commun
. 2021 Feb;
27:100315.
PMID: 33571801
Models of human cancer, to be useful, must replicate human disease with high fidelity. Our focus in this study is rat xenograft brain tumors as a model of human embedded...
12.
Sabedot T, Malta T, Snyder J, Nelson K, Wells M, deCarvalho A, et al.
Neuro Oncol
. 2021 Feb;
23(9):1494-1508.
PMID: 33560371
Background: The detection of somatic mutations in cell-free DNA (cfDNA) from liquid biopsy has emerged as a noninvasive tool to monitor the follow-up of cancer patients. However, the significance of...
13.
Ye L, Reznik E, Korn J, Lin F, Yang G, Malesky K, et al.
Oncotarget
. 2020 Feb;
11(4):443-451.
PMID: 32064048
There is a compelling need for new therapeutic strategies for glioblastoma multiforme (GBM). Preclinical target and therapeutic discovery for GBMs is primarily conducted using cell lines grown in serum-containing media,...
14.
Snyder J, Poisson L, Noushmehr H, Castro A, deCarvalho A, Robin A, et al.
Per Med
. 2019 Mar;
16(2):145-156.
PMID: 30816054
Marked progress has been made recently in the treatment of patients with central nervous system (CNS) tumors, especially gliomas. However, because of the relative rarity of these tumors compared with...
15.
Gonawala S, Aryal M, Ewing J, deCarvalho A, Kalkanis S, Ali M
J Nanomed Nanotechnol
. 2019 Jan;
9(5).
PMID: 30656065
Introduction of polymeric nanoparticles in cancer therapeutics is widely investigated since nanomedicine often enables the intratumoral delivery of drugs with increased efficacy with minimal side effects. In this study MRI...
16.
deCarvalho A, Kim H, Poisson L, Winn M, Mueller C, Cherba D, et al.
Nat Genet
. 2018 Apr;
50(5):708-717.
PMID: 29686388
To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft models derived...
17.
Shimada K, Reznik E, Stokes M, Krishnamoorthy L, Bos P, Song Y, et al.
Cell Chem Biol
. 2018 Mar;
25(5):585-594.e7.
PMID: 29576531
Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we report that the compound NSC319726 binds copper to induce oxidative stress and arrest glioblastoma-patient-derived cells at picomolar...
18.
Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, et al.
Cancer Cell
. 2018 Jan;
33(1):152.
PMID: 29316430
No abstract available.
19.
Irtenkauf S, Sobiechowski S, Hasselbach L, Nelson K, Transou A, Carlton E, et al.
Comp Med
. 2017 Aug;
67(4):300-314.
PMID: 28830577
Glioblastoma is an aggressive primary brain tumor predominantly localized to the cerebral cortex. We developed a panel of patient-derived mouse orthotopic xenografts (PDOX) for preclinical drug studies by implanting cancer...
20.
Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, et al.
Cancer Cell
. 2017 Jul;
32(1):42-56.e6.
PMID: 28697342
We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional subtypes designated as proneural, mesenchymal, and classical. Transcriptomic subtype multiplicity correlated with increased...