Ana C Amaral
Overview
Explore the profile of Ana C Amaral including associated specialties, affiliations and a list of published articles.
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15
Citations
514
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0
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Recent Articles
1.
Aguero C, Dhaynaut M, Amaral A, Moon S, Neelamegam R, Scapellato M, et al.
Acta Neuropathol
. 2024 Jan;
147(1):25.
PMID: 38280071
We and others have shown that [F]-Flortaucipir, the most validated tau PET tracer thus far, binds with strong affinity to tau aggregates in Alzheimer's (AD) but has relatively low affinity...
2.
Taddei R, Perbet R, Mate de Gerando A, Wiedmer A, Sanchez-Mico M, Stewart T, et al.
JAMA Neurol
. 2023 Oct;
80(11):1209-1221.
PMID: 37812432
Importance: Factors associated with synapse loss beyond amyloid-β plaques and neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in Alzheimer disease (AD) and be relevant for...
3.
Petrozziello T, Amaral A, Dujardin S, Farhan S, Chan J, Trombetta B, et al.
Brain Pathol
. 2021 Nov;
32(2):e13035.
PMID: 34779076
Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, several studies report alterations in tau phosphorylation in both sporadic and familial ALS. Recently, we have...
4.
Petrozziello T, Bordt E, Mills A, Kim S, Sapp E, Devlin B, et al.
Mol Neurobiol
. 2021 Nov;
59(1):683-702.
PMID: 34757590
Understanding the mechanisms underlying amyotrophic lateral sclerosis (ALS) is crucial for the development of new therapies. Previous studies have demonstrated that mitochondrial dysfunction is a key pathogenetic event in ALS....
5.
Church N, Weissner W, Galler J, Amaral A, Rosene D, McGaughy J, et al.
Behav Neurosci
. 2021 Sep;
135(5):629-641.
PMID: 34582223
Prenatal protein malnutrition (PPM) alters the developing brain including changes in monoaminergic systems and attention. In the present study, we used in vivo microdialysis to examine the relationship between PPM,...
6.
Marquie M, Aguero C, Amaral A, Villarejo-Galende A, Ramanan P, Siao Tick Chong M, et al.
Acta Neuropathol Commun
. 2019 Oct;
7(1):164.
PMID: 31661038
Introduction: Chronic traumatic encephalopathy (CTE) is a tauopathy associated to repetitive head trauma. There are no validated in vivo biomarkers of CTE and a definite diagnosis can only be made...
7.
Wegmann S, Bennett R, Delorme L, Robbins A, Hu M, McKenzie D, et al.
Sci Adv
. 2019 Jun;
5(6):eaaw6404.
PMID: 31249873
The incidence of Alzheimer's disease (AD), which is characterized by progressive cognitive decline that correlates with the spread of tau protein aggregation in the cortical mantle, is strongly age-related. It...
8.
Mokler D, McGaughy J, Bass D, Morgane P, Rosene D, Amaral A, et al.
Front Neurosci
. 2019 Mar;
13:136.
PMID: 30890908
Exposure to prenatal protein malnutrition (PPM) leads to a reprogramming of the brain, altering executive functions involving the prefrontal cortex (PFC). In this study we used microdialysis to assess the...
9.
Aguero C, Dhaynaut M, Normandin M, Amaral A, Guehl N, Neelamegam R, et al.
Acta Neuropathol Commun
. 2019 Mar;
7(1):37.
PMID: 30857558
[F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of...
10.
Barroeta-Espar I, Weinstock L, Perez-Nievas B, Meltzer A, Siao Tick Chong M, Amaral A, et al.
Neurobiol Dis
. 2018 Oct;
121:327-337.
PMID: 30336198
Our group has previously studied the brains of some unique individuals who are able to tolerate robust amounts of Alzheimer's pathological lesions (amyloid plaques and neurofibrillary tangles) without experiencing dementia...