An Van Laethem
Overview
Explore the profile of An Van Laethem including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
280
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Recent Articles
11.
Claerhout S, Decraene D, Van Laethem A, Van Kelst S, Agostinis P, Garmyn M
J Invest Dermatol
. 2006 Aug;
127(2):429-38.
PMID: 16932738
Upon irradiation with a high dose of UVB, keratinocytes undergo apoptosis as a protective mechanism. In previous work, we demonstrated the existence of an early-activated UVB-induced apoptotic pathway in growth...
12.
Verschooten L, Claerhout S, Van Laethem A, Agostinis P, Garmyn M
Photochem Photobiol
. 2006 May;
82(4):1016-23.
PMID: 16709145
Adequate photoprotection is essential to control UV-related disorders, including sunburn, photoaging and photocarcinogenisis. Sun avoidance, protection of skin with clothing, and sunscreens are presently the best way of photoprotection, assuming...
13.
Claerhout S, Van Laethem A, Agostinis P, Garmyn M
Photochem Photobiol Sci
. 2006 Feb;
5(2):199-207.
PMID: 16465306
The incidence of squamous cell carcinoma of the skin is rising worldwide for decades. Chronic exposure to sunlight is the most important environmental risk factor for this type of skin...
14.
Assefa Z, Van Laethem A, Garmyn M, Agostinis P
Biochim Biophys Acta
. 2005 Jun;
1755(2):90-106.
PMID: 15964692
Epidemiological and experimental evidences have established solar ultraviolet (UV) radiation as the leading cause of skin cancers. Specifically, the frequency of non-melanoma skin cancer, one of the malignancies with the...
15.
Van Laethem A, Claerhout S, Garmyn M, Agostinis P
Int J Biochem Cell Biol
. 2005 May;
37(8):1547-53.
PMID: 15896663
Sunburn cells are keratinocytes undergoing apoptosis after they have received a physiological UVB dose that irreversibly and severely damaged their DNA or other chromophores. If these cells would escape programmed...
16.
Huygens A, Kamuhabwa A, Van Laethem A, Roskams T, Van Cleynenbreugel B, van Poppel H, et al.
Int J Oncol
. 2005 May;
26(6):1691-7.
PMID: 15870887
The aim of this study was to explore the hypothesis of oxygen depletion during light irradiation as a possible explanation for the incomplete response seen after hypericin-mediated photodynamic therapy (PDT)...
17.
Van Laethem A, Van Kelst S, Lippens S, Declercq W, Vandenabeele P, Janssens S, et al.
FASEB J
. 2004 Sep;
18(15):1946-8.
PMID: 15388671
This study establishes that activation of p38 MAPK by UVB represents a crucial signal required for the conformational change and translocation of Bax to the mitochondria in human keratinocytes. UVB-induced...
18.
Decraene D, Van Laethem A, Agostinis P, De Peuter L, Degreef H, Bouillon R, et al.
J Invest Dermatol
. 2004 Jun;
123(1):207-12.
PMID: 15191562
In previous work, we have described an early-activated and ultraviolet B (UVB)-induced apoptotic pathway in human keratinocytes, which can be completely inhibited by AKT activation. We now compared this response...