An-Sofie Lenaerts
Overview
Explore the profile of An-Sofie Lenaerts including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
425
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0
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Recent Articles
1.
Papandreou A, Singh N, Gianfrancesco L, Budinger D, Barwick K, Agrotis A, et al.
bioRxiv
. 2023 Sep;
PMID: 37745522
Beta-Propeller Protein-Associated Neurodegeneration (BPAN) is one of the commonest forms of Neurodegeneration with Brain Iron Accumulation, caused by mutations in the gene encoding the autophagy-related protein, WDR45. The mechanisms linking...
2.
Hakanpaa L, Abouelezz A, Lenaerts A, Culfa S, Algie M, Barlund J, et al.
J Cell Biol
. 2023 May;
222(8).
PMID: 37233325
Reticular adhesions (RAs) consist of integrin αvβ5 and harbor flat clathrin lattices (FCLs), long-lasting structures with similar molecular composition as clathrin-mediated endocytosis (CME) carriers. Why FCLs and RAs colocalize is...
3.
Nakanoh S, Kadiwala J, Pinte L, Morell C, Lenaerts A, Vallier L
PLoS One
. 2022 Nov;
17(11):e0269122.
PMID: 36413521
RB is a well-known cell cycle regulator controlling the G1 checkpoint. Previous reports have suggested that it can influence cell fate decisions not only by regulating cell proliferation and survival...
4.
Tilson S, Morell C, Lenaerts A, Park S, Hu Z, Jenkins B, et al.
Hepatology
. 2021 Jul;
74(6):2998-3017.
PMID: 34288010
Background And Aims: NAFLD is a growing public health burden. However, the pathogenesis of NAFLD has not yet been fully elucidated, and the importance of genetic factors has only recently...
5.
Bertero A, Brown S, Madrigal P, Osnato A, Ortmann D, Yiangou L, et al.
Nature
. 2018 Mar;
555(7695):256-259.
PMID: 29489750
The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated through the intracellular effectors SMAD2 and SMAD3 (hereafter SMAD2/3), whose...
6.
Petersen R, Lambourne J, Javierre B, Grassi L, Kreuzhuber R, Ruklisa D, et al.
Nat Commun
. 2017 Jul;
8:16058.
PMID: 28703137
Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine....
7.
Johnstone M, Maclean A, Heyrman L, Lenaerts A, Nordin A, Nilsson L, et al.
Mol Neuropsychiatry
. 2016 May;
1(3):175-190.
PMID: 27239468
Robust statistical, genetic and functional evidence supports a role for in the aetiology of major mental illness. Furthermore, many of its protein-binding partners show evidence for involvement in the pathophysiology...
8.
Van Den Bossche M, Strazisar M, Cammaerts S, Liekens A, Vandeweyer G, Depreeuw V, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2013 Mar;
162B(3):273-82.
PMID: 23505263
Over the last years, genome-wide studies consistently showed an increased burden of rare copy number variants (CNVs) in schizophrenia patients, supporting the "common disease, rare variant" hypothesis in at least...
9.
Van Den Bossche M, Docx L, Morrens M, Cammaerts S, Strazisar M, Bervoets C, et al.
Neuropsychobiology
. 2012 Sep;
66(3):158-66.
PMID: 22948380
Background: The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive...
10.
Van Den Bossche M, Johnstone M, Strazisar M, Pickard B, Goossens D, Lenaerts A, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2012 Aug;
159B(7):812-22.
PMID: 22911887
From a number of genome-wide association studies it was shown that de novo and/or rare copy number variants (CNVs) are found at an increased frequency in neuropsychiatric diseases. In this...