Amy E Lovett-Racke
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Explore the profile of Amy E Lovett-Racke including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Zeng Q, Guo H, Tang N, Renavikar P, Karandikar N, Lovett-Racke A, et al.
J Biomed Sci
. 2025 Feb;
32(1):26.
PMID: 39972304
Background: The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown. Th17...
2.
Deffenbaugh J, Jung K, Murphy S, Liu Y, Rau C, Petersen-Cherubini C, et al.
J Neuroimmunol
. 2024 Aug;
394:578408.
PMID: 39098102
Epstein-Barr virus (EBV) is deemed a necessary, yet insufficient factor in the development of multiple sclerosis (MS). In this study, myelin basic protein-specific transgenic T cell receptor mice were infected...
3.
Rau C, Severin M, Lee P, Deffenbaugh J, Liu Y, Murphy S, et al.
Eur J Immunol
. 2024 Apr;
54(6):e2350548.
PMID: 38634287
Transforming growth factor beta (TGF-β) signaling is essential for a balanced immune response by mediating the development and function of regulatory T cells (Tregs) and suppressing autoreactive T cells. Disruption...
4.
Petersen-Cherubini C, Liu Y, Deffenbaugh J, Murphy S, Xin M, Rau C, et al.
J Neuroimmunol
. 2024 Jan;
387:578282.
PMID: 38183947
Multiple sclerosis (MS) is a demyelinating disease characterized by infiltration of autoreactive T cells into the central nervous system (CNS). In order to understand how activated, autoreactive T cells are...
5.
Petersen-Cherubini C, Murphy S, Xin M, Liu Y, Deffenbaugh J, Jahan I, et al.
Eur J Immunol
. 2023 Oct;
54(1):e2350561.
PMID: 37850588
Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the CNS. A defining characteristic of MS is the ability of autoreactive T lymphocytes to cross the blood-brain barrier and mediate...
6.
Goldschmidt C, Galetta S, Lisak R, Balcer L, Hellman A, Racke M, et al.
Neurol Neuroimmunol Neuroinflamm
. 2022 Oct;
10(1).
PMID: 36270950
A woman presented at age 18 years with partial myelitis and diplopia and experienced multiple subsequent relapses. Her MRI demonstrated T2 abnormalities characteristic of multiple sclerosis (MS) (white matter ovoid...
7.
Gombash S, Lee P, Sawdai E, Lovett-Racke A
Front Neurol
. 2022 Jun;
13:796933.
PMID: 35651353
Vitamin D insufficiency during childhood has been linked to the development of multiple sclerosis (MS), typically an adult-onset inflammatory demyelinating disease of the central nervous system (CNS). Since vitamin D...
8.
Kraus E, Kakuk-Atkins L, Farinas M, Jeffers M, Lovett-Racke A, Yang Y
J Neuroimmunol
. 2021 Aug;
359:577675.
PMID: 34403862
Myelin-specific CD4 T effector cells (Teffs), Th1 and Th17 cells, are encephalitogenic in experimental autoimmune encephalomyelitis (EAE), a well-defined murine model of multiple sclerosis (MS) and implicated in MS pathogenesis....
9.
Lovett-Racke A, Yang Y, Liu Y, Gormley M, Kraus E, Graham C, et al.
J Neuroimmunol
. 2021 Aug;
359:577676.
PMID: 34364105
B cell depletion therapy has been shown to be beneficial in multiple sclerosis (MS). However, the mechanism by which B cell depletion mediates its beneficial effects in MS is still...
10.
Aqel S, Yang X, Kraus E, Song J, Farinas M, Zhao E, et al.
JCI Insight
. 2021 Jan;
6(4).
PMID: 33411696
Reestablishing an appropriate balance between T effector cells (Teff) and Tregs is essential for correcting autoimmunity. Multiple sclerosis (MS) is an immune-mediated chronic CNS disease characterized by neuroinflammation, demyelination, and...