Amy C Doty
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Explore the profile of Amy C Doty including associated specialties, affiliations and a list of published articles.
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7
Citations
105
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Recent Articles
1.
Li D, Deng Y, Achab A, Bharathan I, Hopkins B, Yu W, et al.
ACS Med Chem Lett
. 2021 Mar;
12(3):389-396.
PMID: 33738066
Indoleamine-2,3-dioxygenase-1 (IDO1) has emerged as an attractive target for cancer immunotherapy. An automated ligand identification system screen afforded the tetrahydroquinoline class of novel IDO1 inhibitors. Potency and pharmacokinetic (PK) were...
2.
Pu Q, Zhang H, Guo L, Cheng M, Doty A, Ferguson H, et al.
ACS Med Chem Lett
. 2020 Aug;
11(8):1548-1554.
PMID: 32832022
Indoleamine-2,3-dioxygenase 1 (IDO1) inhibition and its combination with immune checkpoint inhibitors like have drawn considerable attention from both academia and the pharmaceutical industry. Here, we describe the discovery of a...
3.
Zhang H, Liu K, Pu Q, Achab A, Ardolino M, Cheng M, et al.
ACS Med Chem Lett
. 2019 Nov;
10(11):1530-1536.
PMID: 31749906
Checkpoint inhibitors have demonstrated unprecedented efficacy and are evolving to become standard of care for certain types of cancers. However, low overall response rates often hamper the broad utility and...
4.
Doty A, Weinstein D, Hirota K, Olsen K, Ackermann R, Wang Y, et al.
J Control Release
. 2017 Mar;
256:19-25.
PMID: 28342981
Little is known about the underlying effects controlling in vitro-in vivo correlations (IVIVCs) for biodegradable controlled release microspheres. Most reports of IVIVCs that exist are empirical in nature, typically based...
5.
Doty A, Zhang Y, Weinstein D, Wang Y, Choi S, Qu W, et al.
Eur J Pharm Biopharm
. 2016 Nov;
113:24-33.
PMID: 27865933
In vitro tests for controlled release PLGA microspheres in their current state often do not accurately predict in vivo performance of these products during formulation development. Here, we introduce a...
6.
Doty A, Hirota K, Olsen K, Sakamoto N, Ackermann R, Feng M, et al.
Biomaterials
. 2016 Oct;
109:88-96.
PMID: 27693924
Here we describe development of a silicone rubber/stainless steel mesh cage implant system, much like that used to assess biocompatibility of biomaterials [1], for easy removal of injectable polymer microspheres...
7.
Hirota K, Doty A, Ackermann R, Zhou J, Olsen K, Feng M, et al.
J Control Release
. 2016 Aug;
244(Pt B):302-313.
PMID: 27565212
Release testing of parental controlled release microspheres is an essential step in controlling quality and predicting the duration of efficacy. In the first of a two-part study, we examined the...