Amir Segev
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Explore the profile of Amir Segev including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
276
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Recent Articles
1.
Segev A, Heady L, Crewe M, Madabhushi R
Cell Rep
. 2024 Feb;
43(2):113809.
PMID: 38377005
We trapped catalytically engaged topoisomerase IIβ (TOP2B) in covalent DNA cleavage complexes (TOP2Bccs) and mapped their positions genome-wide in cultured mouse cortical neurons. We report that TOP2Bcc distribution varies with...
2.
Crewe M, Segev A, Rueda R, Madabhushi R
Mol Neurobiol
. 2023 Nov;
61(6):3240-3257.
PMID: 37979036
Multivalent binding of CTCF to variable DNA sequences is thought to underlie its ability to mediate diverse cellular functions. CTCF typically binds a 20 base-pair consensus DNA sequence, but the...
3.
Cuesta S, Burdisso P, Segev A, Kourrich S, Sperandio V
Cell Host Microbe
. 2022 Nov;
30(11):1615-1629.e5.
PMID: 36323315
Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we use mice colonized with Citrobacter rodentium or the human γ-Proteobacteria commensal Escherichia coli HS as...
4.
Delint-Ramirez I, Konada L, Heady L, Rueda R, Jacome A, Marlin E, et al.
Mol Cell
. 2022 Oct;
82(20):3794-3809.e8.
PMID: 36206766
Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their transcription, and yet, the mechanisms that...
5.
Delint-Ramirez I, Segev A, Pavuluri A, Self D, Kourrich S
Front Neurosci
. 2020 Aug;
14:698.
PMID: 32760242
The consequence of repeated cocaine exposure and prolonged abstinence on glutamate receptor expression in the nucleus accumbens has been extensively studied. However, the early effects of cocaine on NMDAR signaling...
6.
Segev A, Yanagi M, Scott D, Southcott S, Lister J, Tan C, et al.
Mol Psychiatry
. 2018 Jul;
25(11):2832-2843.
PMID: 30038231
Recent findings from in vivo-imaging and human post-mortem tissue studies in schizophrenic psychosis (SzP), have demonstrated functional and molecular changes in hippocampal subfields that can be associated with hippocampal hyperexcitability....
7.
Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, et al.
Neuropsychopharmacology
. 2018 Jul;
43(10):2017-2027.
PMID: 29977073
Posttraumatic stress disorder (PTSD) is characterized by the reexperiencing of a traumatic event and is associated with slower extinction of fear responses. Impaired extinction of fearful associations to trauma-related cues...
8.
Yun S, Reynolds R, Petrof I, White A, Rivera P, Segev A, et al.
Nat Med
. 2018 Jun;
24(9):1482.
PMID: 29934536
In the version of this article originally published, a URL provided in the Methods section was incorrect. The URL had a solidus at the end but should have appeared as...
9.
Delint-Ramirez I, Garcia-Oscos F, Segev A, Kourrich S
Mol Psychiatry
. 2018 Jun;
25(3):680-691.
PMID: 29880884
Drug-induced enhanced dopamine (DA) signaling in the brain is a canonical mechanism that initiates addiction processes. However, indirect evidence suggests that cocaine also triggers non-canonical, DA-independent, mechanisms that contribute to...
10.
Yun S, Reynolds R, Petrof I, White A, Rivera P, Segev A, et al.
Nat Med
. 2018 Apr;
24(5):658-666.
PMID: 29662202
Major depressive disorder (MDD) is considered a 'circuitopathy', and brain stimulation therapies hold promise for ameliorating MDD symptoms, including hippocampal dysfunction. It is unknown whether stimulation of upstream hippocampal circuitry,...