Amie L Holmes
Overview
Explore the profile of Amie L Holmes including associated specialties, affiliations and a list of published articles.
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26
Citations
467
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Recent Articles
1.
Xie H, Smith L, Holmes A, Zheng T, Wise Sr J
Environ Mol Mutagen
. 2016 Apr;
57(4):282-7.
PMID: 27040722
Cobalt is a toxic metal used in various industrial applications leading to adverse lung effects by inhalation. Cobalt is considered a possible human carcinogen with the lung being a primary...
2.
Wise S, Holmes A, Liou L, Adam R, Wise Sr J
Toxicol Appl Pharmacol
. 2016 Feb;
296:54-60.
PMID: 26908176
Numerous metals are well-known human bladder carcinogens. Despite the significant occupational and public health concern of metals and bladder cancer, the carcinogenic mechanisms remain largely unknown. Chromium, in particular, is...
3.
Martino J, Holmes A, Xie H, Wise S, Wise Sr J
Toxicol Sci
. 2015 Aug;
147(2):490-9.
PMID: 26293554
Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen. Lung tumors are characterized by structural and numerical chromosome instability. Centrosome amplification is a phenotype commonly found in solid tumors,...
4.
Xie H, Holmes A, Wise S, Young J, Wise J, Wise Sr J
Biol Trace Elem Res
. 2015 Mar;
166(1):49-56.
PMID: 25805272
Hexavalent chromium Cr(VI) is a known human lung carcinogen, with solubility playing an important role in its carcinogenic potency. Dermal exposure to Cr(VI) is common and has been associated with...
5.
Qin Q, Xie H, Wise S, Browning C, Thompson K, Holmes A, et al.
Toxicol Sci
. 2014 Sep;
142(1):117-25.
PMID: 25173789
The aim of this study was to focus on hexavalent chromium, [Cr(VI)], a chemical carcinogen and major public health concern, and consider its ability to impact DNA double strand break...
6.
Smith L, Holmes A, Kandpal S, Mason M, Zheng T, Wise Sr J
Toxicol Appl Pharmacol
. 2014 May;
278(3):259-65.
PMID: 24823294
Cobalt exposure is increasing as cobalt demand rises worldwide due to its use in enhancing rechargeable battery efficiency, super-alloys, and magnetic products. Cobalt is considered a possible human carcinogen with...
7.
Holmes A, Joyce K, Xie H, Falank C, Hinz J, Wise Sr J
Mutat Res
. 2014 Feb;
762:1-9.
PMID: 24561002
Depleted uranium (DU) is extensively used in both industry and military applications. The potential for civilian and military personnel exposure to DU is rising, but there are limited data on...
8.
Kost G, Patierno S, Wise S, Holmes A, Wise Sr J, Ceryak S
Mutat Res
. 2012 May;
735(1-2):51-5.
PMID: 22583656
Inappropriate survival signaling after DNA damage may facilitate clonal expansion of genetically compromised cells, and it is known that protein tyrosine phosphatase (PTP) inhibitors activate key survival pathways. In this...
9.
Holmes A, Wise J
Biochem Soc Trans
. 2010 Dec;
38(6):1687-90.
PMID: 21118148
Exposure to toxic and carcinogenic metals is widespread; however, their mechanisms of action remain largely unknown. One potential mechanism for metal-induced carcinogenicity and toxicity is centrosome amplification. Here we review...
10.
Wise Sr J, Wise S, Holmes A, Lacerte C, Shaffiey F, Aboueissa A
Comp Biochem Physiol C Toxicol Pharmacol
. 2010 Mar;
152(1):91-8.
PMID: 20211760
In this study we directly compared soluble and particulate chromate cytotoxicity and genotoxicity in human (Homo sapiens) and sea lion (Eumetopias jubatus) lung fibroblasts. Our results show that hexavalent chromium...