Amelie Schreieck
Overview
Explore the profile of Amelie Schreieck including associated specialties, affiliations and a list of published articles.
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8
Citations
440
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0
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Recent Articles
1.
Daveson A, Stubbs R, Polasek T, Isola J, Anderson R, Tye-Din J, et al.
Lancet Gastroenterol Hepatol
. 2024 Nov;
10(1):44-54.
PMID: 39521016
Background: IMU-856 is an orally available and systemically acting small molecule modulator of sirtuin 6 (SIRT6), a protein that serves as a transcriptional regulator of bowel epithelium regeneration. We aimed...
2.
Stegmann K, Dickmanns A, Heinen N, Blaurock C, Karrasch T, Breithaupt A, et al.
iScience
. 2022 May;
25(5):104293.
PMID: 35492218
The nucleoside analog N4-hydroxycytidine (NHC) is the active metabolite of the prodrug molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 incorporates NHC into its RNA, resulting in...
3.
Sherwood J, Brown H, Rettino A, Schreieck A, Clark G, Claes B, et al.
ESMO Open
. 2017 Oct;
2(4):e000235.
PMID: 29018576
Introduction: This study assessed mutation detection and functional characteristics across 13 distinct technologies and assays available in clinical practice, in a blinded manner. Methods: Five distinct -mutant cell lines were...
4.
Schuller R, Forne I, Straub T, Schreieck A, Texier Y, Shah N, et al.
Mol Cell
. 2016 Jan;
61(2):305-14.
PMID: 26799765
The carboxy-terminal domain (CTD) of RNA polymerase II (Pol II) consists of heptad repeats with the consensus motif Y1-S2-P3-T4-S5-P6-S7. Dynamic phosphorylation of the CTD coordinates Pol II progression through the...
5.
Schreieck A, Easter A, Etzold S, Wiederhold K, Lidschreiber M, Cramer P, et al.
Nat Struct Mol Biol
. 2014 Jan;
21(2):175-179.
PMID: 24413056
At the 3' ends of protein-coding genes, RNA polymerase (Pol) II is dephosphorylated at tyrosine residues (Tyr1) of its C-terminal domain (CTD). In addition, the associated cleavage-and-polyadenylation factor (CPF) cleaves...
6.
Mayer A, Heidemann M, Lidschreiber M, Schreieck A, Sun M, Hintermair C, et al.
Science
. 2012 Jun;
336(6089):1723-5.
PMID: 22745433
In different phases of the transcription cycle, RNA polymerase (Pol) II recruits various factors via its C-terminal domain (CTD), which consists of conserved heptapeptide repeats with the sequence Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7). We...
7.
Mayer A, Schreieck A, Lidschreiber M, Leike K, Martin D, Cramer P
Mol Cell Biol
. 2012 Feb;
32(7):1321-31.
PMID: 22290438
During transcription elongation, RNA polymerase II (Pol II) binds the general elongation factor Spt5. Spt5 contains a repetitive C-terminal region (CTR) that is required for cotranscriptional recruitment of the Paf1...
8.
Geiger S, Lorenzen K, Schreieck A, Hanecker P, Kostrewa D, Heck A, et al.
Mol Cell
. 2010 Aug;
39(4):583-94.
PMID: 20797630
The eukaryotic RNA polymerases Pol I, II, and III use different promoters to transcribe different classes of genes. Promoter usage relies on initiation factors, including TFIIF and TFIIE, in the...