Ambra Del Grosso
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Explore the profile of Ambra Del Grosso including associated specialties, affiliations and a list of published articles.
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16
Citations
171
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Recent Articles
1.
Del Grosso A, Carpi S, De Sarlo M, Scaccini L, Colagiorgio L, Alabed H, et al.
Biomed Pharmacother
. 2024 Feb;
173:116351.
PMID: 38422660
Krabbe disease (KD) is a rare disorder arising from the deficiency of the lysosomal enzyme galactosylceramidase (GALC), leading to the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous...
2.
Alabed H, Del Grosso A, Bellani V, Urbanelli L, Carpi S, De Sarlo M, et al.
Biomolecules
. 2023 Oct;
13(10).
PMID: 37892244
Krabbe disease is a rare neurodegenerative disease with an autosomal recessive character caused by a mutation in the gene. The mutation leads to an accumulation of psychosine and a subsequent...
3.
Mezzena R, Del Grosso A, Pellegrino R, Alabed H, Emiliani C, Tonazzini I, et al.
Biomedicines
. 2023 Mar;
11(3).
PMID: 36979906
Krabbe disease (KD) is a genetic disorder caused by the absence of the galactosylceramidase (GALC) functional enzyme. No cure is currently available. Here, we investigate the mechanotransduction process in primary...
4.
Carpi S, Del Grosso A, De Sarlo M, Colagiorgio L, Scaccini L, Tonazzini I, et al.
Biomedicines
. 2022 Dec;
10(12).
PMID: 36551902
Twitcher (Twi) is a neurological Krabbe disease (KD, or globoid cell leukodystrophy) spontaneous mutant line in mice. The genome of the Twi mouse presents a single nucleotide polymorphism (SNP), leading...
5.
Begarani F, DAutilia F, Ferri G, Pesce L, Azzarello F, De Lorenzi V, et al.
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886970
Here we provide demonstration that fast fluorescence fluctuation spectroscopy is a fast and robust approach to extract information on the dynamics of molecules enclosed within subcellular nanostructures (e.g., organelles or...
6.
Del Grosso A, Parlanti G, Mezzena R, Cecchini M
Adv Drug Deliv Rev
. 2022 Jul;
188:114464.
PMID: 35878795
Lysosomal storage disorders (LSDs) are a vast group of more than 50 clinically identified metabolic diseases. They are singly rare, but they affect collectively 1 on 5,000 live births. They...
7.
Del Grosso A, Parlanti G, Angella L, Giordano N, Tonazzini I, Ottalagana E, et al.
JIMD Rep
. 2022 Jan;
63(1):50-65.
PMID: 35028271
Krabbe disease (KD; or globoid cell leukodystrophy) is an autosomal recessive lysosomal storage disorder caused by deficiency of the galactosylceramidase (GALC) enzyme. No cure is currently available for KD. Clinical...
8.
Tonazzini I, Cerri C, Del Grosso A, Antonini S, Allegra M, Caleo M, et al.
Biomolecules
. 2020 Dec;
11(1).
PMID: 33374753
Krabbe disease (KD, or globoid cell leukodystrophy; OMIM #245200) is an inherited neurodegenerative condition belonging to the class of the lysosomal storage disorders. It is caused by genetic alterations in...
9.
Del Grosso A, Galliani M, Angella L, Santi M, Tonazzini I, Parlanti G, et al.
Sci Adv
. 2019 Dec;
5(11):eaax7462.
PMID: 31799395
Lysosomal storage disorders (LSDs) result from an enzyme deficiency within lysosomes. The systemic administration of the missing enzyme, however, is not effective in the case of LSDs with central nervous...
10.
Del Grosso A, Angella L, Tonazzini I, Moscardini A, Giordano N, Caleo M, et al.
Neurobiol Dis
. 2019 May;
129:195-207.
PMID: 31108173
Krabbe disease (KD) is a childhood leukodystrophy with no cure currently available. KD is due to a deficiency of a lysosomal enzyme called galactosyl-ceramidase (GALC) and is characterized by the...