Amanda Janesick
Overview
Explore the profile of Amanda Janesick including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
1155
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Recent Articles
1.
Benkafadar N, Sato M, Ling A, Janesick A, Scheibinger M, Jan T, et al.
Dev Cell
. 2023 Dec;
59(2):280-291.e5.
PMID: 38128539
Hearing loss is a chronic disease affecting millions of people worldwide, yet no restorative treatment options are available. Although non-mammalian species can regenerate their auditory sensory hair cells, mammals cannot....
2.
Janesick A, Shelansky R, Gottscho A, Wagner F, Williams S, Rouault M, et al.
Nat Commun
. 2023 Dec;
14(1):8353.
PMID: 38114474
Single-cell and spatial technologies that profile gene expression across a whole tissue are revolutionizing the resolution of molecular states in clinical samples. Current commercially available technologies provide whole transcriptome single-cell,...
3.
Scheibinger M, Janesick A, Benkafadar N, Ellwanger D, Jan T, Heller S
Cell Rep
. 2022 Sep;
40(13):111432.
PMID: 36170825
The avian utricle, a vestibular organ of the inner ear, displays turnover of sensory hair cells throughout life. This is in sharp contrast to the mammalian utricle, which shows limited...
4.
Giffen K, Li Y, Liu H, Zhao X, Zhang C, Shen R, et al.
Sci Adv
. 2022 Apr;
8(14):eabk0942.
PMID: 35394837
Lysosomes contribute to cellular homeostasis via processes including macromolecule degradation, nutrient sensing, and autophagy. Defective proteins related to lysosomal macromolecule catabolism are known to cause a range of lysosomal storage...
5.
Benkafadar N, Janesick A, Scheibinger M, Ling A, Jan T, Heller S
Cell Rep
. 2021 Mar;
34(12):108902.
PMID: 33761357
Sensory hair cells are prone to apoptosis caused by various drugs including aminoglycoside antibiotics. In mammals, this vulnerability results in permanent hearing loss because lost hair cells are not regenerated....
6.
Janesick A, Scheibinger M, Benkafadar N, Kirti S, Ellwanger D, Heller S
Cell Rep
. 2021 Mar;
34(12):108900.
PMID: 33761346
In contrast to mammals, birds recover naturally from acquired hearing loss, which makes them an ideal model for inner ear regeneration research. Here, we present a validated single-cell RNA sequencing...
7.
Janesick A, Tang W, Ampig K, Blumberg B
Sci Rep
. 2019 Jun;
9(1):8275.
PMID: 31164691
Znf703 is an RAR- and Wnt-inducible transcription factor that exhibits a complex expression pattern in the developing embryo: Znf703 mRNA is found in the early circumblastoporal ring, then later throughout...
8.
Chappell V, Janesick A, Blumberg B, Fenton S
Toxicol Sci
. 2018 Nov;
166(2):332-344.
PMID: 30496566
Tetrabromobisphenol A (TBBPA) is the most common flame retardant used in electrical housings, circuit boards, and automobiles. High-throughput screening and binding assays have identified TBBPA as an agonist for human...
9.
Janesick A, Tang W, Shioda T, Blumberg B
Development
. 2018 Aug;
145(18).
PMID: 30111657
The developing vertebrate embryo is exquisitely sensitive to retinoic acid (RA) concentration, particularly during anteroposterior patterning. In contrast to Nodal and Wnt signaling, RA was not previously considered to be...
10.
Chamorro-Garcia R, Shoucri B, Willner S, Kach H, Janesick A, Blumberg B
Environ Health Perspect
. 2018 May;
126(5):057006.
PMID: 29787037
Background: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, in construction materials, and in medical devices. Previous animal studies showed detrimental effects of DBT...