Amanda C Sharko
Overview
Explore the profile of Amanda C Sharko including associated specialties, affiliations and a list of published articles.
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12
Citations
340
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Recent Articles
1.
Ding X, Liang J, Sharko A, Hilimire T, Li J, Loskutov J, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2414501121.
PMID: 39541354
Triple-negative breast cancers (TNBC) are treated primarily by chemotherapy and lack clinically validated therapeutic targets. In particular, inhibitors of the PI3K/AKT/mTOR pathway, abnormally activated in many breast cancers, failed to...
2.
Ding X, Sharko A, McDermott M, Schools G, Chumanevich A, Ji H, et al.
Proc Natl Acad Sci U S A
. 2022 Aug;
119(32):e2201073119.
PMID: 35914167
Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic...
3.
Sharko A, Lim C, McDermott M, Hennes C, Philavong K, Aiken T, et al.
Cells
. 2021 Jan;
10(1).
PMID: 33445730
Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which...
4.
McDermott M, Sharko A, Munie J, Kassler S, Melendez T, Lim C, et al.
Cells
. 2020 Mar;
9(3).
PMID: 32155786
CDK7, a transcriptional cyclin-dependent kinase, is emerging as a novel cancer target. Triple-negative breast cancers (TNBC) but not estrogen receptor-positive (ER+) breast cancers have been reported to be uniquely sensitive...
5.
Sharko A, Fadel J, Kaigler K, Wilson M
Physiol Behav
. 2016 Oct;
178:93-102.
PMID: 27746261
Identifying the neurobiological mechanisms that underlie differential sensitivity to stress is critical for understanding the development and expression of stress-induced disorders, such as post-traumatic stress disorder (PTSD). Preclinical studies have...
6.
Butler R, Oliver E, Sharko A, Parilla-Carrero J, Kaigler K, Fadel J, et al.
Behav Brain Res
. 2016 Jan;
304:92-101.
PMID: 26821289
Rats exposed to the odor of a predator or to the elevated plus maze (EPM) express unique unconditioned fear behaviors. The extended amygdala has previously been demonstrated to mediate the...
7.
Sharko A, Kaigler K, Fadel J, Wilson M
Alcohol
. 2016 Jan;
50:19-25.
PMID: 26775553
High rates of comorbidity for anxiety and alcohol-use disorders suggest a causal relationship between these conditions. Previous work demonstrates basal anxiety levels in outbred Long-Evans rats correlate with differences in...
8.
Agoglia A, Sharko A, Psilos K, Holstein S, Reid G, Hodge C
Alcohol Clin Exp Res
. 2015 Feb;
39(3):463-75.
PMID: 25703719
Background: Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes alcohol dependence and addiction. The transition from binge alcohol drinking to alcohol addiction likely involves...
9.
Sharko A, Kaigler K, Fadel J, Wilson M
Alcohol Clin Exp Res
. 2012 Jul;
37 Suppl 1:E172-80.
PMID: 22834974
Background: Although alcohol use disorders and anxiety disorders are highly comorbid, the relationship between these 2 disorders is not fully understood. Previous work from our laboratory shows that anxiety-like behavior...
10.
Besheer J, Grondin J, Cannady R, Sharko A, Faccidomo S, Hodge C
Biol Psychiatry
. 2009 Nov;
67(9):812-22.
PMID: 19897175
Background: Systemic modulation of Group I and II metabotropic glutamate receptors (mGluRs) regulate ethanol self-administration in a variety of animal models. Although these receptors are expressed in reward-related brain regions,...