Amal A Rahmeh
Overview
Explore the profile of Amal A Rahmeh including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
675
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Recent Articles
1.
Kennedy E, Denslow A, Hewett J, Kong L, de Almeida A, Bryant J, et al.
Nat Commun
. 2022 Oct;
13(1):5907.
PMID: 36207308
The therapeutic effectiveness of oncolytic viruses (OVs) delivered intravenously is limited by the development of neutralizing antibody responses against the virus. To circumvent this limitation and to enable repeated systemic...
2.
Wang X, Zhang S, Zheng R, Yue F, Lin S, Rahmeh A, et al.
Oncotarget
. 2016 Jan;
7(5):6294-313.
PMID: 26819372
PDIP46 (SKAR, POLDIP3) was discovered through its interaction with the p50 subunit of human DNA polymerase δ (Pol δ). Its functions in DNA replication are unknown. PDIP46 associates with Pol...
3.
Liang B, Li Z, Jenni S, Rahmeh A, Morin B, Grant T, et al.
Cell
. 2015 Jul;
162(2):314-327.
PMID: 26144317
The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral ribonucleoprotein as template, a non-canonical sequence of...
4.
Morin B, Kranzusch P, Rahmeh A, Whelan S
Curr Opin Virol
. 2013 Apr;
3(2):103-10.
PMID: 23602472
Negative-sense (NS) RNA viruses deliver into cells a mega-dalton RNA-protein complex competent for transcription. Within this complex, the RNA is protected in a nucleocapsid protein (NP) sheath which the viral...
5.
Rahmeh A, Morin B, Schenk A, Liang B, Heinrich B, Brusic V, et al.
Proc Natl Acad Sci U S A
. 2012 Aug;
109(36):14628-33.
PMID: 22908284
The RNA-dependent RNA polymerase (RdRP) of nonsegmented negative-sense RNA viruses consists of a large catalytic protein (L) and a phosphoprotein cofactor (P). During infection, the RdRP replicates and transcribes the...
6.
Heinrich B, Morin B, Rahmeh A, Whelan S
J Virol
. 2012 Jun;
86(16):8720-9.
PMID: 22674999
The vesicular stomatitis virus (VSV) nucleoprotein (N) associates tightly with the viral genomic RNA. This N-RNA complex constitutes the template for the RNA-dependent RNA polymerase L, which engages the nucleocapsid...
7.
Morin B, Rahmeh A, Whelan S
EMBO J
. 2012 Jan;
31(5):1320-9.
PMID: 22246179
The minimal RNA synthesis machinery of non-segmented negative-strand RNA viruses comprises a genomic RNA encased within a nucleocapsid protein (N-RNA), and associated with the RNA-dependent RNA polymerase (RdRP). The RdRP...
8.
Rahmeh A, Zhou Y, Xie B, Li H, Lee E, Lee M
Biochemistry
. 2011 Dec;
51(1):416-24.
PMID: 22148433
DNA polymerase delta (Pol δ) is a central enzyme for eukaryotic DNA replication and repair. Pol δ is a complex of four subunits p125, p68, p50, and p12. The functional...
9.
Tekes G, Rahmeh A, Whelan S
PLoS Pathog
. 2011 Jun;
7(6):e1002073.
PMID: 21655110
The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral...
10.
Rahmeh A, Schenk A, Danek E, Kranzusch P, Liang B, Walz T, et al.
Proc Natl Acad Sci U S A
. 2010 Nov;
107(46):20075-80.
PMID: 21041632
Nonsegmented negative-strand (NNS) RNA viruses initiate infection by delivering into the host cell a highly specialized RNA synthesis machine comprising the genomic RNA completely encapsidated by the viral nucleocapsid protein...