Alvaro Mallagaray
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Explore the profile of Alvaro Mallagaray including associated specialties, affiliations and a list of published articles.
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30
Citations
263
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Recent Articles
1.
Mallagaray A, Rudolph L, Lindloge M, Molbitz J, Thomsen H, Schmelter F, et al.
Angew Chem Int Ed Engl
. 2023 Jun;
62(35):e202306154.
PMID: 37341676
Nuclear Magnetic Resonance (NMR) spectra of human serum and plasma show, besides metabolites and lipoproteins, two characteristic signals termed GlycA and B arising from the acetyl groups of glycoprotein glycans...
2.
Trastoy B, Du J, Cifuente J, Rudolph L, Garcia-Alija M, Klontz E, et al.
Nat Commun
. 2023 Mar;
14(1):1705.
PMID: 36973249
Bacterial pathogens have evolved intricate mechanisms to evade the human immune system, including the production of immunomodulatory enzymes. Streptococcus pyogenes serotypes secrete two multi-modular endo-β-N-acetylglucosaminidases, EndoS and EndoS2, that specifically...
3.
Creutznacher R, Schulze-Niemand E, Konig P, Stanojlovic V, Mallagaray A, Peters T, et al.
Biochemistry
. 2023 Feb;
62(5):1032-1043.
PMID: 36808948
Accelerated spontaneous deamidation of asparagine 373 and subsequent conversion into an isoaspartate has been shown to attenuate the binding of histo blood group antigens (HBGAs) to the protruding domain (P-domain)...
4.
Maass T, Ssebyatika G, Bruckner M, Breckwoldt L, Krey T, Mallagaray A, et al.
Chemistry
. 2022 Sep;
28(71):e202202614.
PMID: 36161798
We have used NMR experiments to explore the binding of selected glycans and glycomimetics to the SARS CoV-2 spike glycoprotein (S-protein) and to its receptor binding domain (RBD). STD NMR...
5.
Khan Khilji S, Goerdeler F, Frensemeier K, Warschkau D, Luhle J, Fandi Z, et al.
Cell Chem Biol
. 2022 Jun;
29(8):1353-1361.e6.
PMID: 35705094
The development of antibodies that target specific glycan structures on cancer cells or human pathogens poses a significant challenge due to the immense complexity of naturally occurring glycans. Automated glycan...
6.
Creutznacher R, Maass T, Dulfer J, Feldmann C, Hartmann V, Lane M, et al.
Commun Biol
. 2022 Jun;
5(1):563.
PMID: 35680964
Norovirus capsids are icosahedral particles composed of 90 dimers of the major capsid protein VP1. The C-terminus of the VP1 proteins forms a protruding (P)-domain, mediating receptor attachment, and providing...
7.
Muhlberg L, Alarcin T, Maass T, Creutznacher R, Kuchler R, Mallagaray A
J Biomol NMR
. 2022 Apr;
76(3):59-74.
PMID: 35397749
NMR spectroscopy allows the study of biomolecules in close-to-native conditions. Structural information can be inferred from the NMR spectra when an assignment is available. Protein assignment is usually a time-consuming...
8.
Maass T, Westermann L, Creutznacher R, Mallagaray A, Dulfer J, Uetrecht C, et al.
Biomol NMR Assign
. 2022 Jan;
16(1):97-107.
PMID: 35050443
The protruding domain (P-domain) of the murine norovirus (MNV) capsid protein VP1 is essential for infection. It mediates receptor binding and attachment of neutralizing antibodies. Protein NMR studies into interactions...
9.
Peters T, Creutznacher R, Maass T, Mallagaray A, Ogrissek P, Taube S, et al.
Biochem Soc Trans
. 2021 Dec;
50(1):347-359.
PMID: 34940787
Infection with human noroviruses requires attachment to histo blood group antigens (HBGAs) via the major capsid protein VP1 as a primary step. Several crystal structures of VP1 protruding domain dimers,...
10.
Schmelter F, Foh B, Mallagaray A, Rahmoller J, Ehlers M, Lehrian S, et al.
Front Mol Biosci
. 2021 Dec;
8:737039.
PMID: 34938772
Coronavirus disease 2019 (COVID-19) is a viral infection affecting multiple organ systems of great significance for metabolic processes. Thus, there is increasing interest in metabolic and lipoprotein signatures of the...