Alper Akay
Overview
Explore the profile of Alper Akay including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
181
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0
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Recent Articles
1.
Sultanova Z, Shen A, Hencel K, Carlsson H, Crighton Z, Clifton D, et al.
Aging Cell
. 2025 Jan;
e14481.
PMID: 39853894
The developmental theory of ageing proposes that age-specific decline in the force of natural selection results in suboptimal levels of gene expression in adulthood, leading to functional senescence. This theory...
2.
Shen A, Hencel K, Parker M, Scott R, Skukan R, Adesina A, et al.
Nucleic Acids Res
. 2024 May;
52(15):9139-9160.
PMID: 38808663
pre-mRNA splicing is a critical feature of eukaryotic gene expression. Both cis- and trans-splicing rely on accurately recognising splice site sequences by spliceosomal U snRNAs and associated proteins. Spliceosomal snRNAs...
3.
Shen A, Hencel K, Parker M, Scott R, Skukan R, Adesina A, et al.
bioRxiv
. 2023 Sep;
PMID: 37745402
pre-mRNA splicing is a critical feature of eukaryotic gene expression. Many eukaryotes use cis-splicing to remove intronic sequences from pre-mRNAs. In addition to cis-splicing, many organisms use trans-splicing to replace...
4.
Kranse O, Beasley H, Adams S, Pires-daSilva A, Bell C, Lilley C, et al.
G3 (Bethesda)
. 2021 Feb;
11(2).
PMID: 33585878
Plant-parasitic nematodes are a continuing threat to food security, causing an estimated 100 billion USD in crop losses each year. The most problematic are the obligate sedentary endoparasites (primarily root...
5.
Berkyurek A, Furlan G, Lampersberger L, Beltran T, Weick E, Nischwitz E, et al.
EMBO J
. 2021 Feb;
40(5):e105565.
PMID: 33533030
PIWI-interacting RNAs (piRNAs) are genome-encoded small RNAs that regulate germ cell development and maintain germline integrity in many animals. Mature piRNAs engage Piwi Argonaute proteins to silence complementary transcripts, including...
6.
Navarro I, Tuorto F, Jordan D, Legrand C, Price J, Braukmann F, et al.
EMBO J
. 2020 Dec;
40(6):e105496.
PMID: 33283887
Methylation of carbon-5 of cytosines (m C) is a post-transcriptional nucleotide modification of RNA found in all kingdoms of life. While individual m C-methyltransferases have been studied, the impact of...
7.
Suen K, Braukmann F, Butler R, Bensaddek D, Akay A, Lin C, et al.
Nat Commun
. 2020 Aug;
11(1):4242.
PMID: 32843637
Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated gene silencing. How small ncRNAs utilise phase separated environments for their function is unclear. We investigated how...
8.
Akay A, Jordan D, Navarro I, Wrzesinski T, Ponting C, Miska E, et al.
BMC Biol
. 2019 Feb;
17(1):14.
PMID: 30777050
Background: Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous...
9.
Akay A, Di Domenico T, Suen K, Nabih A, Parada G, Larance M, et al.
Dev Cell
. 2017 Aug;
42(3):241-255.e6.
PMID: 28787591
Small RNAs play a crucial role in genome defense against transposable elements and guide Argonaute proteins to nascent RNA transcripts to induce co-transcriptional gene silencing. However, the molecular basis of...
10.
van Delft P, Akay A, Huber S, Bueschl C, Rudolph K, Di Domenico T, et al.
Chembiochem
. 2017 Apr;
18(11):979-984.
PMID: 28449301
More than a hundred distinct modified nucleosides have been identified in RNA, but little is known about their distribution across different organisms, their dynamic nature and their response to cellular...