Allen Lin
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Explore the profile of Allen Lin including associated specialties, affiliations and a list of published articles.
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1126
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Recent Articles
1.
Pierce M, Huang Y, Lin A, Franco Nitta C, Kuksin D, Lin B, et al.
J Fluoresc
. 2024 Jan;
35(2):1111-1123.
PMID: 38294633
Apoptosis is the programmed cell death pathway that is critical for maintaining homeostasis, in which cancer cells can evade to ensure survival. For pharmaceutical drug discovery, it is important to...
2.
Hofer R, Lin A, House B, Purvis C, Harris B, Symes S, et al.
J Fish Dis
. 2022 Sep;
46(1):31-45.
PMID: 36088584
Aeromonas salmonicida is a Gram-negative bacterium that can infect a wide host range of fish populations, including salmonids and non-salmonids as well as freshwater and marine life. Some strains of...
3.
Chen H, Liu S, Padula S, Lesman D, Griswold K, Lin A, et al.
Nat Biotechnol
. 2019 Dec;
38(2):165-168.
PMID: 31844291
Here we describe TRACE (T7 polymerase-driven continuous editing), a method that enables continuous, targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase. TRACE induces high...
4.
Wang H, Zhao D, Nguyen L, Wu H, Li L, Dong D, et al.
Leukemia
. 2019 Jul;
34(1):75-86.
PMID: 31337857
The E3 ligase human double minute 2 (HDM2) regulates the activity of the tumor suppressor protein p53. A p53-independent HDM2 expression has been reported on the membrane of cancer cells...
5.
Lin A, Balazs A
Retrovirology
. 2018 Oct;
15(1):66.
PMID: 30285769
Vectored gene delivery of HIV-1 broadly neutralizing antibodies (bNAbs) using recombinant adeno-associated virus (rAAV) is a promising alternative to conventional vaccines for preventing new HIV-1 infections and for therapeutically suppressing...
6.
Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, et al.
Cell Stem Cell
. 2018 Aug;
23(3):355-369.e9.
PMID: 30146412
Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that persist after conventional therapies. Defining the mechanisms underlying MDS HSPC maintenance is...
7.
Zhang B, Truong Nguyen L, Li L, Zhao D, Kumar B, Wu H, et al.
Nat Med
. 2018 Mar;
24(4):450-462.
PMID: 29505034
Leukemia stem cells (LSCs) in individuals with chronic myelogenous leukemia (CML) (hereafter referred to as CML LSCs) are responsible for initiating and maintaining clonal hematopoiesis. These cells persist in the...
8.
Lin A, Ong K, Hobbelen P, King E, Mesher D, Edmunds W, et al.
Clin Infect Dis
. 2016 Dec;
64(5):580-588.
PMID: 28011615
Background: Men who have sex with men (MSM) have a high lifetime risk of anogenital warts and cancers related to infection with human papillomavirus (HPV). They also benefit less from...
9.
Zhang B, Chu S, Agarwal P, Campbell V, Hopcroft L, Jorgensen H, et al.
Blood
. 2016 Sep;
128(23):2671-2682.
PMID: 27621307
Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete...
10.
Qi J, Singh S, Hua W, Cai Q, Chao S, Li L, et al.
Cell Stem Cell
. 2015 Sep;
17(5):597-610.
PMID: 26387755
Acute myeloid leukemia (AML) is driven and sustained by leukemia stem cells (LSCs) with unlimited self-renewal capacity and resistance to chemotherapy. Mutation in the TP53 tumor suppressor is relatively rare...