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Alisson M Gontijo

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Citations 533
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Recent Articles
1.
Fernandez-Acosta M, Zanini R, Heredia F, A Volonte Y, Menezes J, Pruger K, et al.
Proc Natl Acad Sci U S A . 2025 Mar; 122(11):e2420452122. PMID: 40085652
At the end of their growth phase, larvae remodel their bodies, glue themselves to a substrate, and harden their cuticle in preparation for metamorphosis. This process-termed pupariation-is triggered by a...
2.
Imambocus B, Zhou F, Formozov A, Wittich A, Tenedini F, Hu C, et al.
Curr Biol . 2021 Nov; 32(1):149-163.e8. PMID: 34798050
Animals display selective escape behaviors when faced with environmental threats. Selection of the appropriate response by the underlying neuronal network is key to maximizing chances of survival, yet the underlying...
3.
Heredia F, Volonte Y, Pereirinha J, Fernandez-Acosta M, Casimiro A, Belem C, et al.
Nat Commun . 2021 Jun; 12(1):3328. PMID: 34099654
Innate behaviors consist of a succession of genetically-hardwired motor and physiological subprograms that can be coupled to drastic morphogenetic changes. How these integrative responses are orchestrated is not completely understood....
4.
Macedo A, Gontijo A
Gigascience . 2020 Aug; 9(8). PMID: 32761099
Background: The human body is made up of hundreds-perhaps thousands-of cell types and states, most of which are currently inaccessible genetically. Intersectional genetic approaches can increase the number of genetically...
5.
Gontijo A, Garelli A
Mech Dev . 2018 May; 154:44-50. PMID: 29715504
Many insects, like cockroaches, moths, and flies, can regenerate tissues by extending the growth-competent phases of their life cycle. The molecular and cellular players mediating this coordination between tissue growth...
6.
Garelli A, Heredia F, Casimiro A, Macedo A, Nunes C, Garcez M, et al.
Nat Commun . 2015 Oct; 6:8732. PMID: 26510564
How different organs in the body sense growth perturbations in distant tissues to coordinate their size during development is poorly understood. Here we mutate an invertebrate orphan relaxin receptor gene,...
7.
de Castro Marcondes J, Oliveira M, Gontijo A, de Camargo J, Salvadori D
PLoS One . 2014 Jan; 9(1):e86162. PMID: 24465937
Bladder cancer is one of the most common genitourinary neoplasms in industrialized countries. Multifocality and high recurrence rates are prominent clinical features of this disease and contribute to its high...
8.
Garelli A, Gontijo A, Miguela V, Caparros E, Dominguez M
Science . 2012 May; 336(6081):579-82. PMID: 22556250
Developing animals frequently adjust their growth programs and/or their maturation or metamorphosis to compensate for growth disturbances (such as injury or tumor) and ensure normal adult size. Such plasticity entails...
9.
Gontijo A, Miguela V, Whiting M, Woodruff R, Dominguez M
Nat Commun . 2011 May; 2. PMID: 21610726
Genomes can encode a variety of proteins with unrelated architectures and activities. It is known that protein-coding genes of de novo origin have significantly contributed to this diversity. However, the...
10.
Gontijo A, Aubert S, Roelens I, Lakowski B
BMC Genet . 2009 Mar; 10:14. PMID: 19302704
Background: Presenilin proteins are part of a complex of proteins that can cleave many type I transmembrane proteins, including Notch Receptors and the Amyloid Precursor Protein, in the middle of...