Alison Joyce
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Explore the profile of Alison Joyce including associated specialties, affiliations and a list of published articles.
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23
Citations
313
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Recent Articles
11.
Zhu L, Wang Y, Joyce A, Djura I, Gorovits B
Pharm Res
. 2019 Oct;
36(12):169.
PMID: 31654236
Purpose: The purpose of this study was to validate a ligand binding assay for the quantitation of a monoclonal antibody-based biotherapeutics (PF-57781346) in samples collected via capillary microsampling to support...
12.
Xiang Y, Parng C, Olson K, Seletskaia E, Gorovits B, Jani D, et al.
AAPS J
. 2019 Mar;
21(3):46.
PMID: 30927117
Immunogenicity is a major challenge for protein therapeutics which can potentially reduce drug efficacy and safety and is often being monitored by anti-drug antibody (ADA) and neutralizing antibody (NAb) assays....
13.
Weng Y, Ishino T, Sievers A, Talukdar S, Chabot J, Tam A, et al.
Sci Rep
. 2018 Mar;
8(1):4241.
PMID: 29523796
Pharmacological administration of FGF21 analogues has shown robust body weight reduction and lipid profile improvement in both dysmetabolic animal models and metabolic disease patients. Here we report the design, optimization,...
14.
Chunyk A, Joyce A, Fischer S, Dysinger M, Mikulskis A, Jeromin A, et al.
AAPS J
. 2017 Dec;
20(1):10.
PMID: 29196830
An in-depth evaluation of the Quanterix© Simoa™ platform was undertaken by scientists from the AAPS Emerging Technologies Focus Group to determine the overall performance of the technology as well as...
15.
Parng C, Markiewicz V, Chen J, Leary B, Duriga N, Dyleski L, et al.
J Pharm Sci
. 2017 Apr;
106(8):2136-2143.
PMID: 28389265
FXa is a recombinant human FXa variant which is currently being evaluated in the clinic for treating intracerebral hemorrhage. The aim of our studies is to investigate overall pharmacokinetics, pharmacodynamics,...
16.
Avery L, Wang M, Kavosi M, Joyce A, Kurz J, Fan Y, et al.
MAbs
. 2016 May;
8(6):1064-78.
PMID: 27232760
Therapeutic antibodies continue to develop as an emerging drug class, with a need for preclinical tools to better predict in vivo characteristics. Transgenic mice expressing human neonatal Fc receptor (hFcRn)...
17.
Wang M, Ishino T, Joyce A, Tam A, Duan W, Lin L, et al.
J Biosci Bioeng
. 2015 Jan;
119(6):657-60.
PMID: 25575972
This investigation used in vivo and in vitro tools to study pharmacokinetics and glycosylation of two monomeric antibodies produced either transiently by HEK293 cells or stably by Chinese hamster ovary...
18.
Stevenson L, Amaravadi L, Myler H, Salazar-Fontana L, Gorovits B, Kirshner S, et al.
Bioanalysis
. 2014 Dec;
6(24):3355-68.
PMID: 25534792
The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion in the evolving field of bioanalysis, took place in Universal City, California, USA. Close to...
19.
Fischer S, Joyce A, Spengler M, Yang T, Zhuang Y, Fjording M, et al.
AAPS J
. 2014 Oct;
17(1):93-101.
PMID: 25331105
Ligand binding assays (LBAs) have been the method of choice for protein analyte measurements for more than four decades. Over the years, LBA methods have improved in sensitivity and achieved...
20.
Chen J, Wang M, Joyce A, DeFranco D, Kavosi M, Xu X, et al.
Pharm Res
. 2014 May;
31(10):2810-21.
PMID: 24844406
Purpose: To assess the application of succinimidyl iodobenzoate (SIB) iodination method in labeling biotherapeutics to study their pharmacokinetics (PK) and biodistribution. Method: An IgG molecule (protein-01) and a 40 KDa...