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Alison B Fleming

Explore the profile of Alison B Fleming including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 221
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Recent Articles
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Brennan M, Kopecky E, Marseilles A, OConnor M, Fleming A
Pain Manag . 2017 Nov; 7(6):461-472. PMID: 29171358
Aim: To further characterize the pharmacokinetics of Xtampza ER. Subjects & Methods: This was an open-label, randomized, active-controlled, five-treatment, five-period, naltrexone-blocked, cross-over study. Healthy subjects received five equivalent oxycodone doses:...
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Mayock S, Saim S, Fleming A
Clin Drug Investig . 2017 Nov; 37(12):1203. PMID: 29094281
Following correction should be noted.
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Butler S, Black R, Fleming A
Pain Med . 2017 Oct; 19(8):1613-1627. PMID: 29016905
Objective: Some crush-resistant tablet formulations (CRTs) reduce prescription opioid abuse by nonoral routes of administration (ROAs), especially insufflation and injection, while oral abuse increases. Oral abuse involving product manipulation vs...
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Mayock S, Saim S, Fleming A
Clin Drug Investig . 2017 Sep; 37(12):1117-1124. PMID: 28940174
Background And Objective: Extended-release (ER) opioids are associated with high rates of abuse. Recreational opioid users often manipulate ER formulations to achieve a high plasma concentration in a short amount...
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Kopecky E, Fleming A, Levy-Cooperman N, OConnor M, Sellers E
J Clin Pharmacol . 2016 Sep; 57(4):500-512. PMID: 27669664
Oxycodone DETERx (Collegium Pharmaceutical Inc, Canton, Massachusetts) is an extended-release, microsphere-in-capsule, abuse-deterrent formulation designed to retain its extended-release properties after tampering (eg, chewing/crushing). This randomized, double-blind, placebo-controlled, triple-dummy study evaluated...
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McCarberg B, Kopecky E, OConnor M, Marseilles A, Varanasi R, Thompson C, et al.
Curr Med Res Opin . 2016 Sep; 32(12):1975-1982. PMID: 27668546
Background: Patients with chronic pain may experience difficulty swallowing, in part due to worsening disease, comorbid conditions, iatrogenic etiology, or age. Patients or caregivers may manipulate extended-release (ER) opioid formulations...
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Fleming A, Scungio T, Grima M, Mayock S
J Opioid Manag . 2016 Feb; 12(1):57-65. PMID: 26908304
Objective: Abuse of prescription analgesics is a well-recognized problem, with nearly 2 million people aged 12 years or older initiating nonmedical use of pain relievers in 2012. The prevalence of...
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Webster L, Kopecky E, Smith M, Fleming A
Pain Med . 2016 Jan; 17(6):1112-30. PMID: 26814256
Objective: Evaluate the human abuse potential (HAP) of an experimental, microsphere-in-capsule formulation of extended-release oxycodone (oxycodone DETERx®) (herein "DETERx"). Design: Randomized, double-blind, double-dummy, positive- and placebo-controlled, single-dose, four-phase, four-treatment, crossover...