Alice Buonfiglioli
Overview
Explore the profile of Alice Buonfiglioli including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
443
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Recent Articles
1.
Mesentier-Louro L, Goldman C, Ndayisaba A, Buonfiglioli A, Rooklin R, Schuldt B, et al.
bioRxiv
. 2025 Feb;
PMID: 39975381
The pathological hallmark of neurodegenerative disease is the aberrant post-translational modification and aggregation of proteins leading to the formation of insoluble protein inclusions. Genetic factors like are known to increase...
2.
Buonfiglioli A, Kubler R, Missall R, Jong R, Chan S, Haage V, et al.
Brain Behav Immun
. 2024 Nov;
123():1127-1146.
PMID: 39500415
Prenatal infections and activation of the maternal immune system have been proposed to contribute to causing neurodevelopmental disorders (NDDs), chronic conditions often linked to brain abnormalities. Microglia are the resident...
3.
Jantti H, Kistemaker L, Buonfiglioli A, de Witte L, Malm T, Hol E
Adv Neurobiol
. 2024 Aug;
37:545-568.
PMID: 39207712
New in vitro models provide an exciting opportunity to study live human microglia. Previously, a major limitation in understanding human microglia in health and disease has been their limited availability....
4.
Buonfiglioli A, Kubler R, Missall R, Jong R, Chan S, Haage V, et al.
bioRxiv
. 2024 Jun;
PMID: 38826204
Prenatal infections and activation of the maternal immune system have been proposed to contribute to causing neurodevelopmental disorders (NDDs), chronic conditions often linked to brain abnormalities. Microglia are the resident...
5.
Haage V, Tuddenham J, Comandante-Lou N, Bautista A, Monzel A, Chiu R, et al.
bioRxiv
. 2024 Feb;
PMID: 38370689
While efforts to identify microglial subtypes have recently accelerated, the relation of transcriptomically defined states to function has been largely limited to annotations. Here, we characterize a set of pharmacological...
6.
Klammer M, Dzaye O, Wallach T, Kruger C, Gaessler D, Buonfiglioli A, et al.
Front Immunol
. 2021 Sep;
12:715774.
PMID: 34589086
The chaperone protein Unc-93 homolog B1 (UNC93B1) regulates internalization, trafficking, and stabilization of nucleic acid-sensing Toll-like receptors (TLR) in peripheral immune cells. We sought to determine UNC93B1 expression and its...
7.
Buonfiglioli A, Hambardzumyan D
Acta Neuropathol Commun
. 2021 Mar;
9(1):54.
PMID: 33766119
Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors, characterized by malignant growth, invasion into the brain parenchyma, and resistance to therapy. GBM is a heterogeneous...
8.
Ifuku M, Hinkelmann L, Kuhrt L, Efe I, Kumbol V, Buonfiglioli A, et al.
Acta Neuropathol Commun
. 2020 Sep;
8(1):159.
PMID: 32912327
Microglia are the primary immune-competent cells of the central nervous system (CNS) and sense both pathogen- and host-derived factors through several receptor systems including the Toll-like receptor (TLR) family. Although...
9.
Elmadany N, Logiacco F, Buonfiglioli A, Haage V, Wright-Jin E, Schattenberg A, et al.
Neurobiol Dis
. 2020 Aug;
144():105030.
PMID: 32736084
As critical regulators of brain homeostasis, microglia are influenced by numerous factors, including sex and genetic mutations. To study the impact of these factors on microglia biology, we employed genetically...
10.
Huang Y, Zhang Q, Lubas M, Yuan Y, Yalcin F, Efe I, et al.
J Neurosci
. 2020 Jul;
40(33):6428-6443.
PMID: 32631940
In murine experimental glioma models, TLR3 or TLR9 activation of microglial/macrophages has been shown to impair glioma growth, which could, however, not been verified in recent clinical trials. We therefore...