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» Authors » Ali S Alfardan

Ali S Alfardan

Explore the profile of Ali S Alfardan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 89
Followers 0
Related Specialties
Pharmacology
Allergy & Immunology
General Medicine
Top 10 Co-Authors
Sheikh F Ahmad
Ahmed Nadeem
Naif O Al-Harbi
Sabry M Attia
Khalid E Ibrahim
Saleh A Bakheet
Saleh A Alqarni
Samiyah Alshehri
Laila Y Al-Ayadhi
Khalid Alhazzani
Published In
Int Immunopharmacol
Environ Res
Prog Neuropsychopharmacol Biol Psychiatry
Toxics
Biomed Pharmacother
Affiliations
Soon will be listed here.
Recent Articles
1.
DNMT inhibitor, 5-aza-2'-deoxycytidine mitigates di(2-ethylhexyl) phthalate-induced aggravation of psoriasiform inflammation in mice via reduction in global DNA methylation in dermal and peripheral compartments
Alfardan A, Nadeem A, Ahmad S, Al-Harbi N, Alqinyah M, Attia S, et al.
Int Immunopharmacol . 2024 Jun; 137:112503. PMID: 38906008
Psoriasis is classified as an autoimmune disorder characterized by abnormal immune response leading to the development of chronic dermal inflammation. Most individuals have a genetic vulnerability that may be further...
2.
Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells
Alfardan A, Nadeem A, Ahmad S, Al-Harbi N, Alqinyah M, Attia S, et al.
Int Immunopharmacol . 2023 Dec; 126:111293. PMID: 38056199
Psoriasis is a devastating autoimmune illness resulting from excessive keratinocyte growth and leukocyte infiltration into the dermis/epidermis. In the pathogenesis of psoriasis, different immune cells such as myeloid cells and...
3.
Thioredoxin 1 and Thioredoxin Reductase 1 Redox System Is Dysregulated in Neutrophils of Subjects with Autism: In Vitro Effects of Environmental Toxicant, Methylmercury
Alshehri S, Ahmad S, Albekairi N, Alqarni S, Al-Harbi N, Al-Ayadhi L, et al.
Toxics . 2023 Sep; 11(9). PMID: 37755749
Autism spectrum disorder (ASD) is a complex developmental disorder in children that results in abnormal communicative and verbal behaviors. Exposure to heavy metals plays a significant role in the pathogenesis...
4.
Inhibition of ITK Signaling Causes Amelioration in Sepsis-Associated Neuroinflammation and Depression-like State in Mice
Algahtani M, Alshehri S, Alqarni S, Ahmad S, Al-Harbi N, Alqarni S, et al.
Int J Mol Sci . 2023 May; 24(9). PMID: 37175808
Sepsis affects millions of people worldwide and is associated with multiorgan dysfunction that is a major cause of increased morbidity and mortality. Sepsis is associated with several morbidities, such as...
5.
Inhibition of non-receptor tyrosine kinase LCK partially mitigates mixed granulocytic airway inflammation in a murine model of asthma
Alqarni S, Ahmad S, Alqahtani F, Al-Harbi N, Alshehri S, Ibrahim K, et al.
Int Immunopharmacol . 2023 Apr; 119:110225. PMID: 37119678
Asthma affects millions of people worldwide and is one of the most common inflammatory airway diseases. Asthma phenotypes are quite complex and categorized as eosinophilic, mixed granulocytic (presence of both...
6.
CXCR3 antagonist NBI-74330 mitigates joint inflammation in Collagen-Induced arthritis model in DBA/1J mice
Ahmad S, Nadeem A, Ansari M, Bakheet S, Alomar H, Al-Mazroua H, et al.
Int Immunopharmacol . 2023 Apr; 118:110099. PMID: 37018975
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction. We used the CXCR3-specific antagonist NBI-74330 to block T-cell-mediated signaling...
7.
DNA Hypomethylation Is Associated with Increased Inflammation in Peripheral Blood Neutrophils of Children with Autism Spectrum Disorder: Understanding the Role of Ubiquitous Pollutant Di(2-ethylhexyl) Phthalate
Alshamrani A, Alshehri S, Alqarni S, Ahmad S, Alghibiwi H, Al-Harbi N, et al.
Metabolites . 2023 Mar; 13(3). PMID: 36984898
Autism spectrum disorder (ASD) is a multidimensional disorder in which environmental, immune, and genetic factors act in concert to play a crucial role. ASD is characterized by social interaction/communication impairments...
8.
Bruton's tyrosine kinase inhibition suppresses neutrophilic inflammation and restores histone deacetylase 2 expression in myeloid and structural cells in a mixed granulocytic mouse model of asthma
Nadeem A, Alshehri S, Al-Harbi N, Ahmad S, Albekairi N, Alqarni S, et al.
Int Immunopharmacol . 2023 Feb; 117:109920. PMID: 36827920
Asthmatic inflammation is not a single homogenous inflammation but may be categorized into several phenotypes/endotypes. Severe asthma is characterized by mixed granulocytic inflammation in which there is increased presence of...
9.
Acetyl-11-keto-β-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-κB pathways in SJL/J mouse model of experimental autoimmune encephalomyelitis
Nadeem A, Ahmad S, Al-Harbi N, Sarawi W, Attia S, Alanazi W, et al.
Int Immunopharmacol . 2022 Mar; 107:108703. PMID: 35306283
Multiple sclerosis (MS) is characterized by chronic autoimmune inflammation of central nervous system (CNS), i.e. brain and spinal cord. Autoimmune inflammation of the CNS and periphery causes demyelination of axons...
10.
Dysregulated Nrf2 signaling in response to di(2-ethylhexyl) phthalate in neutrophils of children with autism
Nadeem A, Ahmad S, Al-Harbi N, Al-Ayadhi L, Alanazi M, Alfardan A, et al.
Int Immunopharmacol . 2022 Feb; 106:108619. PMID: 35183033
Autism spectrum disorder (ASD) is characterized by constellation of impaired behaviors that include deficits in social interaction/communication and the presence of restricted/repetitive behavioral patterns. Both genetic component and environmental factors...