Alexey V Stepanov
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Explore the profile of Alexey V Stepanov including associated specialties, affiliations and a list of published articles.
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19
Citations
202
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Recent Articles
1.
Stepanova V, Volkov D, Osipova D, Wang W, Hou Y, Pershin D, et al.
Mol Ther Oncol
. 2025 Jan;
32(3):200843.
PMID: 39822756
Hematopoietic stem cell transplantation (HSCT) is widely used to treat patients with life-threatening hematologic and immune system disorders. Current nontargeted chemo-/radiotherapy conditioning regimens cause tissue injury and induce an array...
2.
Lu W, Lyu H, Xiao X, Bai X, Zhang M, Wang J, et al.
Leukemia
. 2024 Apr;
38(6):1419-1422.
PMID: 38632315
No abstract available.
3.
Britanova O, Lupyr K, Staroverov D, Shagina I, Aleksandrov A, Ustyugov Y, et al.
Nat Med
. 2023 Oct;
29(11):2731-2736.
PMID: 37872223
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune therapy,...
4.
Stepanov A, Xie J, Zhu Q, Shen Z, Su W, Kuai L, et al.
Nat Biomed Eng
. 2023 Oct;
8(5):529-543.
PMID: 37798444
On-target off-tumour toxicity limits the anticancer applicability of chimaeric antigen receptor (CAR) T cells. Here we show that the tumour-targeting specificity and activity of T cells with a CAR consisting...
5.
Komedchikova E, Kolesnikova O, Tereshina E, Kotelnikova P, Sogomonyan A, Stepanov A, et al.
Pharmaceutics
. 2023 Jan;
15(1).
PMID: 36678681
Nanoparticle-based chemotherapy is considered to be an effective approach to cancer diagnostics and therapy in modern biomedicine. However, efficient tumor targeting remains a great challenge due to the lack of...
6.
Stepanov A, Kalinin R, Shipunova V, Zhang D, Xie J, Rubtsov Y, et al.
Proc Natl Acad Sci U S A
. 2022 Nov;
119(46):e2210562119.
PMID: 36343224
The development of chimeric antigen receptor (CAR) T cell therapy has become a critical milestone in modern oncotherapy. Despite the remarkable in vitro effectiveness, the problem of safety and efficacy...
7.
Yaroshevich I, Maksimov E, Sluchanko N, Zlenko D, Stepanov A, Slutskaya E, et al.
Commun Biol
. 2021 May;
4(1):539.
PMID: 33972665
Here, we propose a possible photoactivation mechanism of a 35-kDa blue light-triggered photoreceptor, the Orange Carotenoid Protein (OCP), suggesting that the reaction involves the transient formation of a protonated ketocarotenoid...
8.
Zhou X, Wang H, Ji Q, Du M, Liang Y, Li H, et al.
Protein Cell
. 2021 Apr;
12(10):818-823.
PMID: 33909239
No abstract available.
9.
Maksimov E, Zamaraev A, Parshina E, Slonimskiy Y, Slastnikova T, Abdrakhmanov A, et al.
Antioxidants (Basel)
. 2020 Sep;
9(9).
PMID: 32942578
To counteract oxidative stress, antioxidants including carotenoids are highly promising, yet their exploitation is drastically limited by the poor bioavailability and fast photodestruction, whereas current delivery systems are far from...
10.
Mokrushina Y, Golovin A, Smirnov I, Chatziefthimiou S, Stepanova A, Bobik T, et al.
Proc Natl Acad Sci U S A
. 2020 Aug;
117(37):22841-22848.
PMID: 32859757
Quantum mechanics/molecular mechanics (QM/MM) maturation of an immunoglobulin (Ig) powered by supercomputation delivers novel functionality to this catalytic template and facilitates artificial evolution of biocatalysts. We here employ density functional...