Alexey A Lagunin
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Explore the profile of Alexey A Lagunin including associated specialties, affiliations and a list of published articles.
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37
Citations
400
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Recent Articles
1.
Porfireva E, Zadorozhny A, Rudik A, Filimonov D, Lagunin A
Front Immunol
. 2025 Feb;
16:1492751.
PMID: 39975544
Introduction: Primary immunodeficiencies (PIDs) are a group of rare genetic disorders characterized by dysfunction of the immune system components. Early diagnosis and treatment are essential to prevent severe or life-threatening...
2.
Ivanov S, Lagunin A, Tarasova O
Comput Struct Biotechnol J
. 2025 Feb;
23:3559-3574.
PMID: 39963421
Glioblastoma (GBM) is the most common malignant brain tumor with poor overall survival. Current treatment management for GBM has low efficacy, mainly due to high inter-patient heterogeneity. The transcription profiles...
3.
Prediction of Protein Secondary Structures Based on Substructural Descriptors of Molecular Fragments
Zakharov O, Rudik A, Filimonov D, Lagunin A
Int J Mol Sci
. 2024 Dec;
25(23).
PMID: 39684237
The accurate prediction of secondary structures of proteins (SSPs) is a critical challenge in molecular biology and structural bioinformatics. Despite recent advancements, this task remains complex and demands further exploration....
4.
Ivanov S, Rudik A, Lagunin A, Filimonov D, Poroikov V
Mol Inform
. 2024 Jul;
43(12):e202400032.
PMID: 38979651
The analysis of drug-induced gene expression profiles (DIGEP) is widely used to estimate the potential therapeutic and adverse drug effects as well as the molecular mechanisms of drug action. However,...
5.
Dmitriev D, Shilov B, Polunin M, Zadorozhny A, Lagunin A
Int J Mol Sci
. 2023 Dec;
24(24).
PMID: 38139069
Auditory neuropathy spectrum disorder (ANSD) associated with mutations of the OTOF gene is one of the common types of sensorineural hearing loss of a hereditary nature. Due to its high...
6.
Rudik A, Dmitriev A, Lagunin A, Filimonov D, Poroikov V
ACS Omega
. 2023 Dec;
8(48):45774-45778.
PMID: 38075828
After the biotransformation of xenobiotics in the human body, the biological activity of the metabolites may differ from the activity of parent compounds. Therefore, to assess the overall biological activity...
7.
Paremskaia A, Rudik A, Filimonov D, Lagunin A, Poroikov V, Tarasova O
Viruses
. 2023 Nov;
15(11).
PMID: 38005921
Predicting viral drug resistance is a significant medical concern. The importance of this problem stimulates the continuous development of experimental and new computational approaches. The use of computational approaches allows...
8.
Zhuravleva S, Zadorozhny A, Shilov B, Lagunin A
Life (Basel)
. 2023 Sep;
13(9).
PMID: 37763211
Drug resistance to anticancer drugs is a serious complication in patients with cancer. Typically, drug resistance occurs due to amino acid substitutions (AAS) in drug target proteins. The study aimed...
9.
Kositsyn Y, de Abreu M, Kolesnikova T, Lagunin A, Poroikov V, Harutyunyan H, et al.
Int J Mol Sci
. 2023 Jun;
24(11).
PMID: 37298431
Depression and schizophrenia are two highly prevalent and severely debilitating neuropsychiatric disorders. Both conventional antidepressant and antipsychotic pharmacotherapies are often inefficient clinically, causing multiple side effects and serious patient compliance...
10.
Smirnov A, Rudik A, Filimonov D, Lagunin A
Immunology
. 2023 Mar;
169(4):447-453.
PMID: 36929656
The search for the relationships between CDR3 TCR sequences and epitopes or MHC types is a challenging task in modern immunology. We propose a new approach to develop the classification...