Alexes C Daquinag
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Explore the profile of Alexes C Daquinag including associated specialties, affiliations and a list of published articles.
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816
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Recent Articles
1.
Daquinag A, Gao Z, Yu Y, Kolonin M
Mol Metab
. 2022 Jul;
63:101544.
PMID: 35835372
Objective: Brown adipogenesis and thermogenesis in brown and beige adipose tissue (AT) involve vascular remodeling and sympathetic neuronal guidance. Here, we investigated the molecular mechanism coordinating these processes. Methods: We...
2.
Tovy A, Reyes J, Zhang L, Huang Y, Rosas C, Daquinag A, et al.
Elife
. 2022 May;
11.
PMID: 35635747
DNA Methyltransferase 3 A (DNMT3A) is an important facilitator of differentiation of both embryonic and hematopoietic stem cells. Heterozygous germline mutations in lead to Tatton-Brown-Rahman Syndrome (TBRS), characterized by obesity...
3.
Gao Z, Daquinag A, Yu Y, Kolonin M
Diabetes
. 2022 May;
71(7):1400-1409.
PMID: 35499627
The function of prohibitin-1 (PHB1) in adipocyte mitochondrial respiration, adaptive thermogenesis, and long-chain fatty acid (LCFA) metabolism has been reported. While intracellular PHB1 expression is ubiquitous, cell surface PHB1 localization...
4.
Gao Z, Lu A, Daquinag A, Yu Y, Huard M, Tseng C, et al.
Biomolecules
. 2021 Oct;
11(10).
PMID: 34680151
Duchenne muscular dystrophy (DMD), caused by the loss of dystrophin, remains incurable. Reduction in muscle regeneration with DMD is associated with the accumulation of fibroadipogenic progenitors (FAPs) differentiating into myofibroblasts...
5.
Subramanian S, Daquinag A, AghaAmiri S, Ghosh S, Azhdarinia A, Kolonin M
Cancer Res
. 2021 Oct;
81(22):5756-5764.
PMID: 34607842
Metastasis is the leading cause of cancer-related deaths, and metastatic cancers remain largely incurable due to chemoresistance. Biomarkers of metastatic cells are lacking, and probes that could be used to...
6.
Daquinag A, Gao Z, Fussell C, Immaraj L, Pasqualini R, Arap W, et al.
JCI Insight
. 2021 Jul;
6(17).
PMID: 34314388
The mechanism controlling long-chain fatty acid (LCFA) mobilization from adipose tissue is not well understood. Here, we investigated how the LCFA transporter CD36 regulates this process. By using tissue-specific KO...
7.
Gao Z, Daquinag A, Fussell C, Djehal A, Desaubry L, Kolonin M
Diabetes
. 2021 Jul;
70(10):2204-2212.
PMID: 34257070
Prohibitin-1 (PHB) is a multifunctional protein previously reported to be important for adipocyte function. PHB is expressed on the surface of adipose cells, where it interacts with a long-chain fatty...
8.
Zu Y, Zhao L, Hao L, Mechref Y, Zabet-Moghaddam M, Keyel P, et al.
J Control Release
. 2021 Mar;
333:339-351.
PMID: 33766692
Enhancing thermogenic energy expenditure via promoting the browning of white adipose tissue (WAT) is a potential therapeutic strategy to manage energy imbalance and the consequent comorbidities associated with excess body...
9.
Su F, Daquinag A, Ahn S, Saha A, Dai Y, Zhao Z, et al.
NPJ Precis Oncol
. 2021 Mar;
5(1):26.
PMID: 33753872
Aggressiveness of carcinomas is linked with tumor recruitment of adipose stromal cells (ASC), which is increased in obesity. ASC promote cancer through molecular pathways not fully understood. Here, we demonstrate...
10.
Gao Z, Daquinag A, Fussell C, Zhao Z, Dai Y, Rivera A, et al.
Nat Metab
. 2020 Dec;
2(12):1482-1497.
PMID: 33324010
White and beige adipocytes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) are maintained by proliferation and differentiation of adipose progenitor cells (APCs). Here we use mice with...