Alexei V Korennykh
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Explore the profile of Alexei V Korennykh including associated specialties, affiliations and a list of published articles.
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12
Citations
936
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Recent Articles
1.
Mendez A, Alfaro J, Morales-Soto M, Dar A, McCullagh E, Gotthardt K, et al.
Elife
. 2015 May;
4.
PMID: 25986605
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction,...
2.
van Anken E, Pincus D, Coyle S, Aragon T, Osman C, Lari F, et al.
Elife
. 2014 Dec;
3:e05031.
PMID: 25549299
Insufficient protein-folding capacity in the endoplasmic reticulum (ER) induces the unfolded protein response (UPR). In the ER lumen, accumulation of unfolded proteins activates the transmembrane ER-stress sensor Ire1 and drives...
3.
Korennykh A, Egea P, Korostelev A, Finer-Moore J, Stroud R, Zhang C, et al.
BMC Biol
. 2011 Jul;
9:48.
PMID: 21729334
Background: Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell....
4.
Korennykh A, Korostelev A, Egea P, Finer-Moore J, Stroud R, Zhang C, et al.
BMC Biol
. 2011 Jul;
9:47.
PMID: 21729333
Background: The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1. The endoribonuclease...
5.
Plantinga M, Korennykh A, Piccirilli J, Correll C
Biochemistry
. 2011 Mar;
50(14):3004-13.
PMID: 21417210
Restrictocin and related fungal endoribonucleases from the α-sarcin family site-specifically cleave the sarcin/ricin loop (SRL) on the ribosome to inhibit translation and ultimately trigger cell death. Previous studies showed that...
6.
Li H, Korennykh A, Behrman S, Walter P
Proc Natl Acad Sci U S A
. 2010 Aug;
107(37):16113-8.
PMID: 20798350
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an intracellular signaling pathway that adjusts the protein folding capacity of the ER according to...
7.
Aragon T, van Anken E, Pincus D, Serafimova I, Korennykh A, Rubio C, et al.
Nature
. 2008 Dec;
457(7230):736-40.
PMID: 19079237
Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic cells lead to ER stress and trigger the unfolded protein response (UPR). ER stress is sensed by...
8.
Korennykh A, Egea P, Korostelev A, Finer-Moore J, Zhang C, Shokat K, et al.
Nature
. 2008 Dec;
457(7230):687-93.
PMID: 19079236
Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional transmembrane kinase/endoribonuclease Ire1. Ire1 excises an intron from HAC1 messenger RNA in yeasts and Xbp1 messenger RNA in metozoans...
9.
Plantinga M, Korennykh A, Piccirilli J, Correll C
Biochemistry
. 2008 Aug;
47(34):8912-8.
PMID: 18672906
Restrictocin, a member of the alpha-sarcin family of site-specific endoribonucleases, uses electrostatic interactions to bind to the ribosome and to RNA oligonucleotides, including the minimal specific substrate, the sarcin/ricin loop...
10.
Korennykh A, Plantinga M, Correll C, Piccirilli J
Biochemistry
. 2007 Oct;
46(44):12744-56.
PMID: 17929942
Restrictocin is a site-specific endoribonuclease that inactivates ribosomes by cleaving the sarcin/ricin loop (SRL) of 23S-28S rRNA. Here we present a kinetic and thermodynamic analysis of the SRL cleavage reaction...