Alexandros Kiparissides
Overview
Explore the profile of Alexandros Kiparissides including associated specialties, affiliations and a list of published articles.
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9
Citations
59
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Recent Articles
1.
Elia Venanzi N, Basciu A, Vargiu A, Kiparissides A, Dalby P, Dikicioglu D
J Chem Inf Model
. 2024 Feb;
64(7):2681-2694.
PMID: 38386417
Despite recent advances in computational protein science, the dynamic behavior of proteins, which directly governs their biological activity, cannot be gleaned from sequence information alone. To overcome this challenge, we...
2.
Lularevic M, Racher A, Jaques C, Kiparissides A
Biotechnol Bioeng
. 2019 May;
116(9):2339-2352.
PMID: 31112296
Constraint-based modeling methods, such as Flux Balance Analysis (FBA), have been extensively used to decipher complex, information rich -omics datasets to elicit system-wide behavioral patterns of cellular metabolism. FBA has...
3.
Koutinas M, Kiparissides A, Pistikopoulos E, Mantalaris A
Comput Struct Biotechnol J
. 2014 Apr;
3:e201210022.
PMID: 24688682
The complexity of the regulatory network and the interactions that occur in the intracellular environment of microorganisms highlight the importance in developing tractable mechanistic models of cellular functions and systematic...
4.
Yeo D, Kiparissides A, Cha J, Aguilar-Gallardo C, Polak J, Tsiridis E, et al.
PLoS One
. 2013 Dec;
8(12):e81728.
PMID: 24339957
Background: High proliferative and differentiation capacity renders embryonic stem cells (ESCs) a promising cell source for tissue engineering and cell-based therapies. Harnessing their potential, however, requires well-designed, efficient and reproducible...
5.
Phan T, Saraf P, Kiparissides A, Mantalaris A, Song H, Lim M
Bioprocess Biosyst Eng
. 2013 Apr;
36(11):1689-702.
PMID: 23605055
Stem cell factor (SCF) and erythropoietin (EPO) are two most recognized growth factors that play in concert to control in vitro erythropoiesis. However, exact mechanisms underlying the interplay of these...
6.
Ho Y, Kiparissides A, Pistikopoulos E, Mantalaris A
J Biosci Bioeng
. 2011 Oct;
113(1):88-98.
PMID: 22018734
A systematic computational framework is proposed for studying the underlying mechanisms of hyperosmotic conditions on GS-NS0 antibody production and to predict the optimal hyperosmotic induction time. Both IgG mRNA and...
7.
Kiparissides A, Koutinas M, Moss T, Newman J, Pistikopoulos E, Mantalaris A
PLoS One
. 2011 Feb;
6(2):e14668.
PMID: 21346804
The Notch1 signalling pathway has been shown to control neural stem cell fate through lateral inhibition of mash1, a key promoter of neuronal differentiation. Interaction between the Delta1 ligand of...
8.
Koutinas M, Kiparissides A, Silva-Rocha R, Lam M, Martins Dos Santos V, de Lorenzo V, et al.
Metab Eng
. 2011 Feb;
13(4):401-13.
PMID: 21315172
The majority of models describing the kinetic properties of a microorganism for a given substrate are unstructured and empirical. They are formulated in this manner so that the complex mechanism...
9.
Koutinas M, Lam M, Kiparissides A, Silva-Rocha R, Godinho M, Livingston A, et al.
Environ Microbiol
. 2010 Jun;
12(6):1705-18.
PMID: 20553551
The structure of the extant transcriptional control network of the TOL plasmid pWW0 born by Pseudomonas putida mt-2 for biodegradation of m-xylene is far more complex than one would consider...