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Alexandra Zakharova

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Articles 7
Citations 37
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Recent Articles
1.
Albanaz A, Carrington M, Frolov A, Ganyukova A, Gerasimov E, Kostygov A, et al.
BMC Genomics . 2023 Aug; 24(1):471. PMID: 37605127
Background: Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained notoriety as parasites affecting humans, domestic animals, and agricultural plants. However, the true extent of the group's diversity spreads far...
2.
Zakharova A, Tashyreva D, Butenko A, Morales J, Saura A, Svobodova M, et al.
Curr Biol . 2023 May; 33(13):2690-2701.e5. PMID: 37201521
The stability of endosymbiotic associations between eukaryotes and bacteria depends on a reliable mechanism ensuring vertical inheritance of the latter. Here, we demonstrate that a host-encoded protein, located at the...
3.
Saura A, Zakharova A, Klocek D, Gerasimov E, Butenko A, Macedo D, et al.
mSphere . 2022 Aug; 7(4):e0033522. PMID: 35943162
Leishmaniaviruses (LRVs) have been demonstrated to enhance progression of leishmaniasis, a vector-transmitted disease with a wide range of clinical manifestations that is caused by flagellates of the genus . Here,...
4.
Zakharova A, Albanaz A, Opperdoes F, Skodova-Sverakova I, Zagirova D, Saura A, et al.
PLoS Negl Trop Dis . 2022 Jun; 16(6):e0010510. PMID: 35749562
Leishmaniasis is a parasitic vector-borne disease caused by the protistan flagellates of the genus Leishmania. Leishmania (Viannia) guyanensis is one of the most common causative agents of the American tegumentary...
5.
Polakova E, Albanaz A, Zakharova A, Novozhilova T, Gerasimov E, Yurchenko V
PLoS Negl Trop Dis . 2021 Dec; 15(12):e0010041. PMID: 34965251
Background: Telomeres are indispensable for genome stability maintenance. They are maintained by the telomere-associated protein complex, which include Ku proteins and a telomerase among others. Here, we investigated a role...
6.
Zakharova A, Saura A, Butenko A, Podesvova L, Warmusova S, Kostygov A, et al.
mBio . 2021 Aug; 12(4):e0160621. PMID: 34399629
The closest relative of human pathogen , the trypanosomatid , harbors a bacterial endosymbiont " Pandoraea novymonadis." Based on genomic data, we performed a detailed characterization of the metabolic interactions...
7.
Opperdoes F, Butenko A, Zakharova A, Gerasimov E, Zimmer S, Lukes J, et al.
Pathogens . 2021 Jan; 10(1). PMID: 33466586
A recently redescribed two-flagellar trypanosomatid is insensitive to the classical inhibitors of respiration and thrives under anaerobic conditions. Using genomic and transcriptomic data, we analyzed its genes of the core...