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Alexandra Szalad

Explore the profile of Alexandra Szalad including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 736
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Recent Articles
1.
Wang L, Lu X, Szalad A, Liu X, Zhang Y, Wang X, et al.
Front Cell Neurosci . 2024 Sep; 18:1462228. PMID: 39285940
Background: MicroRNAs (miRNAs) in Schwann cells (SCs) mediate peripheral nerve function. Ablating Dicer, a key gene in miRNA biogenesis, in SCs causes peripheral neuropathy. Exosomes from healthy SCs (SC-Exo) ameliorate...
2.
Wang L, Lu X, Chopp M, Li C, Zhang Y, Szalad A, et al.
PLoS One . 2023 Aug; 18(8):e0290155. PMID: 37594969
Exosomes derived from endothelial cells and Schwann cells have been employed as novel treatments of neurological diseases, including peripheral neuropathy. Exosomal cargo plays a critical role in mediating recipient cell...
3.
Zhang Y, Li C, Qin Y, Cepparulo P, Millman M, Chopp M, et al.
J Extracell Vesicles . 2021 Mar; 10(5):e12073. PMID: 33728031
There are no effective treatments for chemotherapy induced peripheral neuropathy (CIPN). Small extracellular vesicles (sEVs) facilitate intercellular communication and mediate nerve function and tumour progression. We found that the treatment...
4.
Wang L, Chopp M, Szalad A, Lu X, Zhang Y, Wang X, et al.
Diabetes . 2020 Jan; 69(4):749-759. PMID: 31915154
Schwann cell-derived exosomes communicate with dorsal root ganglia (DRG) neurons. The current study investigated the therapeutic effect of exosomes derived from healthy Schwann cells (SC-Exos) on diabetic peripheral neuropathy (DPN)....
5.
Fan B, Li C, Szalad A, Wang L, Pan W, Zhang R, et al.
Diabetologia . 2019 Nov; 63(2):431-443. PMID: 31740984
Aims/hypothesis: Diabetic peripheral neuropathy (DPN) is one of the major complications of diabetes, which contributes greatly to morbidity and mortality. There is currently no effective treatment for this disease. Exosomes...
6.
Wang L, Chopp M, Lu X, Szalad A, Jia L, Liu X, et al.
Brain Res . 2018 Dec; 1707:198-207. PMID: 30500399
Diabetes induces neurovascular dysfunction leading to peripheral neuropathy. MicroRNAs (miRNAs) affect many biological processes and the development of diabetic peripheral neuropathy. In the present study, we investigated whether thymosin-β4 (Tβ4)...
7.
Fan B, Liu X, Szalad A, Wang L, Zhang R, Chopp M, et al.
Front Neurosci . 2018 Nov; 12:795. PMID: 30429771
Cognition impairment and peripheral neuropathy (DPN) are two major complications of diabetes. The aim of the present study is to investigate the effect of sex differences on cognition and DPN...
8.
Wang L, Chopp M, Szalad A, Lu X, Lu M, Zhang T, et al.
Neurosci Res . 2018 Oct; 147:1-8. PMID: 30326249
Angiopoietin-1 (Ang1) and its receptor Tie2 regulate vascular function. Our previous study demonstrated that thymosin beta 4 (Tβ4) ameliorates neurological function of diabetic peripheral neuropathy. Mechanisms underlying the therapeutic effect...
9.
Jia L, Chopp M, Wang L, Lu X, Szalad A, Zhang Z
FASEB J . 2018 Jun; :fj201800597R. PMID: 29932869
Schwann cells actively interact with axons of dorsal root ganglia (DRG) neurons. Exosomes mediate intercellular communication by transferring their biomaterials, including microRNAs (miRs) into recipient cells. We hypothesized that exosomes...
10.
Jia L, Chopp M, Wang L, Lu X, Zhang Y, Szalad A, et al.
Mol Neurobiol . 2018 Apr; 55(12):9089-9099. PMID: 29637443
Hyperglycemia impairs nerve fibers of dorsal root ganglia (DRG) neurons, leading to diabetic peripheral neuropathy (DPN). However, the molecular mechanisms underlying DPN are not fully understood. Using a mouse model...