Alexandra Sharland
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Explore the profile of Alexandra Sharland including associated specialties, affiliations and a list of published articles.
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14
Citations
113
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Recent Articles
1.
Rajapaksha I, Gunarathne L, Asadi K, Cunningham S, Sharland A, Alexander I, et al.
Hepatol Commun
. 2019 Dec;
3(12):1656-1673.
PMID: 31832573
There is a large unmet need for effective therapies for cholestatic disorders, including primary sclerosing cholangitis (PSC), a disease that commonly results in liver failure. Angiotensin (Ang) II of the...
2.
Verma N, Robinson C, Carter N, Wilcox P, Tran G, Wang C, et al.
Front Immunol
. 2019 Nov;
10:2397.
PMID: 31681288
Therapy with alloantigen-specific CD4CD25 T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells. Naïve tTreg...
3.
Chami B, Hossain F, Hambly T, Cai X, Aran R, Fong G, et al.
Front Immunol
. 2019 Mar;
10:380.
PMID: 30899260
Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in...
4.
Paul-Heng M, Leong M, Cunningham E, Bunker D, Bremner K, Wang Z, et al.
JCI Insight
. 2018 Aug;
3(15).
PMID: 30089715
Adeno-associated viral vector-mediated (AAV-mediated) expression of allogeneic major histocompatibility complex class I (MHC class I) in recipient liver induces donor-specific tolerance in mouse skin transplant models in which a class...
5.
Chami B, Barrie N, Cai X, Wang X, Paul M, Morton-Chandra R, et al.
Int J Mol Sci
. 2015 May;
16(5):11101-24.
PMID: 25988387
The acute phase protein serum amyloid A (SAA), a marker of inflammation, induces expression of pro-inflammatory and pro-thrombotic mediators including ICAM-1, VCAM-1, IL-6, IL-8, MCP-1 and tissue factor (TF) in...
6.
Cubitt J, Pennington T, Wang C, Allen R, Bishop A, Sharland A
J Reconstr Microsurg
. 2012 Jan;
28(3):161-6.
PMID: 22274768
Animal models have been used for many years in surgical research to develop different surgical techniques, improve understanding of anatomy and physiology and hone surgical skills. The benefit of such...
7.
Chen G, Wu H, Ma J, Chadban S, Sharland A
Nephrol Dial Transplant
. 2011 May;
26(12):3873-81.
PMID: 21555390
Background: Engagement of Toll-like receptor (TLR) 4 on intrinsic kidney cells is critical for the full development of renal ischaemia-reperfusion injury (IRI). Effects of TLR signalling in renal parenchymal cells...
8.
Sharland A, Logan G, Bishop A, Alexander I
Discov Med
. 2010 Jul;
9(49):519-27.
PMID: 20587341
Vectors based on recombinant adeno-associated virus (AAV) 2/8 hold considerable promise for use in human gene therapy. These vectors are safe, and have minimal immunostimulatory properties. Their combination with efficient,...
9.
10.
Tran P, Christiansen D, Winterhalter A, Brooks A, Gorrell M, Lilienfeld B, et al.
Xenotransplantation
. 2009 Jan;
15(5):321-32.
PMID: 19134162
Background: Xenotransplantation could ameliorate the severe shortage of donor organs. The initial results of transplantation from genetically-modified pig donors to primate recipients suggest that hyperacute rejection can be overcome, but...