Alexandra Sexton-Oates
Overview
Explore the profile of Alexandra Sexton-Oates including associated specialties, affiliations and a list of published articles.
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23
Citations
435
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Recent Articles
1.
Leunissen D, Moonen L, von der Thusen J, den Bakker M, Hillen L, van Weert T, et al.
J Thorac Oncol
. 2024 Nov;
PMID: 39581377
Introduction: Multi-omic studies have identified three molecular separated pulmonary carcinoid (PC) subgroups (A1, A2, B) with distinctive mRNA expression profiles (e.g., orthopedia homeobox protein [OTP], achaete-scute homolog [ASCL1], and hepatocyte...
2.
Werr L, Bartenhagen C, Rosswog C, Cartolano M, Voegele C, Sexton-Oates A, et al.
J Clin Oncol
. 2024 Sep;
43(2):214-225.
PMID: 39348606
Purpose: The clinical course of pulmonary carcinoids ranges from indolent to fatal disease, suggesting that specific molecular alterations drive progression toward the fully malignant state. A similar spectrum of clinical...
3.
Alcala N, Voegele C, Mangiante L, Sexton-Oates A, Clevers H, Fernandez-Cuesta L, et al.
Gigascience
. 2024 Mar;
13.
PMID: 38451475
Background: Organoids are 3-dimensional experimental models that summarize the anatomical and functional structure of an organ. Although a promising experimental model for precision medicine, patient-derived tumor organoids (PDTOs) have currently...
4.
Dayton T, Alcala N, Moonen L, den Hartigh L, Geurts V, Mangiante L, et al.
Cancer Cell
. 2023 Dec;
41(12):2083-2099.e9.
PMID: 38086335
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for patients with NENs are limited, in part due to lack of accurate models....
5.
Fernandez-Cuesta L, Sexton-Oates A, Bayat L, Foll M, Lau S, Leal T
Am Soc Clin Oncol Educ Book
. 2023 May;
43:e390794.
PMID: 37229617
Lung neuroendocrine neoplasms (NENs) encompass a spectrum of neoplasms that are subdivided into the well-differentiated neuroendocrine tumors comprising the low- and intermediate-grade typical and atypical carcinoids, respectively, and the poorly...
6.
Mangiante L, Alcala N, Sexton-Oates A, Di Genova A, Gonzalez-Perez A, Khandekar A, et al.
Nat Genet
. 2023 Mar;
55(4):607-618.
PMID: 36928603
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Through a large series of whole-genome sequencing data, integrated with transcriptomic and epigenomic data using...
7.
Di Genova A, Mangiante L, Sexton-Oates A, Voegele C, Fernandez-Cuesta L, Alcala N, et al.
Gigascience
. 2023 Jan;
12.
PMID: 36705549
Background: Malignant pleural mesothelioma (MPM) is a rare understudied cancer associated with exposure to asbestos. So far, MPM patients have benefited marginally from the genomics medicine revolution due to the...
8.
Khuong-Quang D, Brown L, Wong M, Mayoh C, Sexton-Oates A, Kumar A, et al.
Cold Spring Harb Mol Case Stud
. 2020 Nov;
6(6).
PMID: 33144287
The identification of rearrangements driving expression of neurotrophic receptor tyrosine kinase () family kinases in tumors has become critically important because of the availability of effective, specific inhibitor drugs. Whole-genome...
9.
Dodgshun A, Fukuoka K, Edwards M, Bianchi V, Das A, Sexton-Oates A, et al.
Acta Neuropathol
. 2020 Sep;
140(5):765-776.
PMID: 32895736
Replication repair deficiency (RRD) leading to hypermutation is an important driving mechanism of high-grade glioma (HGG) occurring predominantly in the context of germline mutations in RRD-associated genes. Although HGG presents...
10.
Bleker L, Milgrom J, Sexton-Oates A, Parker D, Roseboom T, Gemmill A, et al.
Front Psychiatry
. 2020 Mar;
11:34.
PMID: 32116849
Purpose Of Article: In a previous pilot randomized controlled trial including 54 pregnant women with depression, maternal mood improved after Cognitive Behavioural Therapy (CBT) compared to treatment as usual (TAU),...