Alexandra P Zorzi
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Explore the profile of Alexandra P Zorzi including associated specialties, affiliations and a list of published articles.
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11
Citations
48
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Recent Articles
1.
Sassine S, Ilinca A, Coltin H, Bittencourt H, Athale U, Bowes L, et al.
Cancer
. 2025 Jan;
131(2):e35673.
PMID: 39801179
Background: Childhood obesity can result in adverse health outcomes. The objectives of this study were to describe the prevalence of obesity and determine the association between obesity at cancer diagnosis...
2.
Judd S, Revon-Riviere G, Grover S, Deyell R, Vanan M, Lewis V, et al.
Cancer Med
. 2024 Feb;
13(3):e7033.
PMID: 38400668
Background: The need for new therapies to improve survival and outcomes in pediatric oncology along with the lack of approval and accessible clinical trials has led to "out-of-trial" use of...
3.
Rodrigues de Oliveira B, Iansavitchous J, Rysan H, Wang W, Sams M, Knight D, et al.
Gene
. 2024 Jan;
900:148131.
PMID: 38216003
Precursor B cell acute lymphoblastic leukemia (Pre-B-ALL) arises from developing B cells and frequently involves mutations in genes encoding transcription factors. In this study, we investigated the function of mutations...
4.
Schwarz U, Woldanski-Travaglini M, Swanston V, Mikhail M, Cacciotti C, Cairney E, et al.
Clin Pharmacol Ther
. 2023 Mar;
113(6):1326-1336.
PMID: 36932910
Mercaptopurine is a cornerstone of maintenance chemotherapy in childhood acute lymphoblastic leukemia (ALL). Its cytotoxic effects are mediated by 6-thioguanine nucleotides (TGNs) incorporation into lymphocyte DNA. Thiopurine methyltransferase (TPMT) inactivates...
5.
Donahoe L, Patel S, Tole S, Zorzi A, Huang L, Honjo O, et al.
Pediatr Hematol Oncol
. 2023 Jan;
40(1):65-69.
PMID: 36701380
A 13-year-old girl presented with hypoxemia during adjuvant chemotherapy for an osteosarcoma of the left distal femur. She underwent an amputation complicated by a post-operative pulmonary embolism (PE). Three months...
6.
Welk B, McArthur E, Zorzi A
JAMA Netw Open
. 2022 Oct;
5(10):e2237545.
PMID: 36264577
Importance: There is a growing focus on environmental sustainability in health care. Objective: To estimate the environmental and patient-level financial benefits associated with the widespread adoption of virtual care during...
7.
Manji A, Samson Y, Deyell R, Johnston D, Lewis V, Zorzi A, et al.
Cancers (Basel)
. 2022 Jun;
14(12).
PMID: 35740650
Oral metronomic topotecan represents a novel approach to chemotherapy delivery which, in preclinical models, may work synergistically with pazopanib in targeting angiogenesis. A phase I and pharmacokinetic (PK) study of...
8.
Loeb D, Lee J, Morgenstern D, Samson Y, Uyttebroeck A, Lyu C, et al.
Cancer Immunol Immunother
. 2022 Mar;
71(10):2485-2495.
PMID: 35262780
Background: We report dose-escalation results from an open-label, phase 1/2 trial evaluating avelumab (anti-PD-L1) in paediatric patients with refractory/relapsed solid tumours. Methods: In phase 1, patients aged < 18 years...
9.
A Canadian Study of Cisplatin Metabolomics and Nephrotoxicity (ACCENT): A Clinical Research Protocol
Jain A, Huang R, Lee J, Jawa N, Lim Y, Guron M, et al.
Can J Kidney Health Dis
. 2021 Nov;
8:20543581211057708.
PMID: 34820133
Background: Cisplatin, a chemotherapy used to treat solid tumors, causes acute kidney injury (AKI), a known risk factor for chronic kidney disease and mortality. AKI diagnosis relies on biomarkers which...
10.
Zorzi A, Yang C, Dell S, Nathan P
J Pediatr Hematol Oncol
. 2015 Oct;
37(8):e447-52.
PMID: 26422284
Pulmonary disease is a significant morbidity among childhood cancer survivors. The aim of this study was to characterize the pulmonary dysfunction experienced by childhood cancer survivors treated with bleomycin. A...