Alexandra Moreira
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Explore the profile of Alexandra Moreira including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
737
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Recent Articles
1.
Sousa B, Bessa M, de Mendonca F, Ferreira P, Moreira A, Pereira-Castro I
Bioinformatics
. 2024 Nov;
40(11).
PMID: 39558592
Summary: APAtizer is a tool designed to analyze alternative polyadenylation events on RNA-sequencing data. The tool handles different file formats, including BAM, htseq, and DaPars bedGraph files. It provides a...
2.
Reis-Claro I, Silva M, Moutinho A, Garcia B, Pereira-Castro I, Moreira A
Front Bioeng Biotechnol
. 2024 Feb;
12:1355957.
PMID: 38380261
The biotechnological landscape has witnessed significant growth in biological therapeutics particularly in the field of recombinant protein production. Here we investigate the function of 3'UTR -regulatory elements in increasing mRNA...
3.
Wilton J, de Mendonca F, Pereira-Castro I, Tellier M, Nojima T, Costa A, et al.
Front Immunol
. 2023 Jun;
14:1182525.
PMID: 37359548
Introduction: Macrophages are essential cells of the immune system that alter their inflammatory profile depending on their microenvironment. Alternative polyadenylation in the 3'UTR (3'UTR-APA) and intronic polyadenylation (IPA) are mechanisms...
4.
Pereira-Castro I, Garcia B, Curinha A, Neves-Costa A, Conde-Sousa E, Moita L, et al.
Cell Mol Life Sci
. 2022 Mar;
79(3):164.
PMID: 35229202
Alternative polyadenylation in the 3' UTR (3' UTR-APA) is a mode of gene expression regulation, fundamental for mRNA stability, translation and localization. In the immune system, it was shown that...
5.
Franco S, Moreira A, Fernandes A, Baptista A
J Optom
. 2021 Dec;
15(4):271-277.
PMID: 34852966
Background: Several studies have suggested that accommodative and non-strabismic binocular dysfunctions are commonly encountered in optometric practice. This study aims to verify whether these findings apply to a Portuguese clinical...
6.
Wilton J, Tellier M, Nojima T, Costa A, Oliveira M, Moreira A
Methods Enzymol
. 2021 Jun;
655:349-399.
PMID: 34183129
Transcription termination in eukaryotic cells involves the recognition of polyadenylation signals (PAS) that signal the site of pre-mRNA cleavage and polyadenylation. Most eukaryotic genes contain multiple PAS that are used...
7.
Pereira-Castro I, Moreira A
Wiley Interdiscip Rev RNA
. 2021 Apr;
12(5):e1653.
PMID: 33843145
Messanger RNA (mRNA) isoforms with alternative 3'-untranslated regions (3'-UTRs) are produced by alternative polyadenylation (APA), which occurs during transcription in most eukaryotic genes. APA fine-tunes gene expression in a cell-type-...
8.
Oliveira M, Freitas J, Pinto P, de Jesus A, Tavares J, Pinho M, et al.
Mol Cell Biol
. 2019 May;
39(15).
PMID: 31085682
Alternative polyadenylation generates transcriptomic diversity, although the physiological impact and regulatory mechanisms involved are still poorly understood. The cell cycle kinase Polo is controlled by alternative polyadenylation in the 3'...
9.
Cruz R, Pereira-Castro I, Almeida M, Moreira A, Cabanes D, Sousa S
Front Cell Infect Microbiol
. 2018 Jun;
8:146.
PMID: 29868502
The host cytoskeleton is a major target for bacterial pathogens during infection. In particular, pathogens usurp the actin cytoskeleton function to strongly adhere to the host cell surface, to induce...
10.
Liu X, Freitas J, Zheng D, Oliveira M, Hoque M, Martins T, et al.
RNA
. 2017 Aug;
23(12):1807-1816.
PMID: 28851752
Alternative polyadenylation (APA) is a mechanism that generates multiple mRNA isoforms with different 3'UTRs and/or coding sequences from a single gene. Here, using 3' region extraction and deep sequencing (3'READS),...