Alexandra L Thomas
Overview
Explore the profile of Alexandra L Thomas including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
157
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0
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Recent Articles
1.
Thomas A, Castellanos K, Mancinelli G, Xia Y, Bauer J, Yazici C, et al.
Clin Transl Gastroenterol
. 2020 May;
11(5):e00152.
PMID: 32358238
Introduction: Acute pancreatitis (AP) is a healthcare challenge with considerable mortality. Treatment is limited to supportive care, highlighting the need to investigate disease drivers and prognostic markers. Activin A is...
2.
Bauer J, Emon M, Staudacher J, Thomas A, Zessner-Spitzenberg J, Mancinelli G, et al.
Sci Rep
. 2020 May;
10(1):7606.
PMID: 32355318
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
3.
Zessner-Spitzenberg J, Thomas A, Krett N, Jung B
Gene Rep
. 2020 Mar;
17.
PMID: 32154442
Although overall survival in colorectal cancer (CRC) is increasing steadily due to progress in screening, therapeutic options and precise diagnostic tools remain scarce. As the understanding of CRC as a...
4.
Bauer J, Emon M, Staudacher J, Thomas A, Zessner-Spitzenberg J, Mancinelli G, et al.
Sci Rep
. 2020 Jan;
10(1):50.
PMID: 31919369
Colorectal cancer (CRC) is the second deadliest cancer in the US due to its propensity to metastasize. Stromal cells and especially cancer-associated fibroblasts (CAF) play a critical biophysical role in...
5.
Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer
Rao S, Stoehr J, Dokic D, Wan L, Decker J, Konopka K, et al.
Oncotarget
. 2017 Nov;
8(48):83925-83939.
PMID: 29137393
Activation of CDK2 in triple negative breast cancer (TNBC) can contribute to non-canonical phosphorylation of a TGFβ signaling component, Smad3, promoting cell proliferation and migration. Inhibition of CDK2 was shown...
6.
Thomas A, Lind H, Hong A, Dokic D, Oppat K, Rosenthal E, et al.
Cell Cycle
. 2017 Jul;
16(15):1453-1464.
PMID: 28678584
Triple negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. Although TNBC is not defined by specific therapeutic targets, a subset of patients...
7.
Decker J, Hobson E, Zhang Y, Shin S, Thomas A, Jeruss J, et al.
Biotechnol Bioeng
. 2017 Mar;
114(9):2085-2095.
PMID: 28322442
The development of resistance to targeted therapeutics is a challenging issue for the treatment of cancer. Cancers that have mutations in BRCA, a DNA repair protein, have been treated with...
8.
Thomas A, Coarfa C, Qian J, Wilkerson J, Rajapakshe K, Krett N, et al.
Nucl Recept Signal
. 2015 Dec;
13:e006.
PMID: 26715915
Glucocorticoids (GC) are a cornerstone of combination therapies for multiple myeloma. However, patients ultimately develop resistance to GCs frequently based on decreased glucocorticoid receptor (GR) expression. An understanding of the...
9.
Schwinefus J, Menssen R, Kohler J, Schmidt E, Thomas A
Biochemistry
. 2013 Nov;
52(51):9339-46.
PMID: 24219229
Glycine-betaine (GB) stabilizes folded protein structure because of its unfavorable thermodynamic interactions with amide oxygen and aliphatic carbon surface area exposed during protein unfolding. However, GB can attenuate nucleic acid...