Alexandra J van den Broek
Overview
Explore the profile of Alexandra J van den Broek including associated specialties, affiliations and a list of published articles.
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19
Citations
451
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Recent Articles
11.
van den Broek A, J van t Veer L, Hooning M, Cornelissen S, Broeks A, Rutgers E, et al.
J Clin Oncol
. 2015 Dec;
34(5):409-18.
PMID: 26700119
Purpose: To determine prospectively overall and age-specific estimates of contralateral breast cancer (CBC) risk for young patients with breast cancer with or without BRCA1/2 mutations. Patients And Methods: A cohort...
12.
van den Broek A, Schmidt M, J van t Veer L, Tollenaar R, van Leeuwen F
PLoS One
. 2015 Mar;
10(3):e0120189.
PMID: 25816289
Objective: Conflicting conclusions have been published regarding breast cancer survival of BRCA1/2 mutation carriers. Here we provide an evidence-based systematic literature review. Methods: Eligible publications were observational studies assessing the...
13.
van den Broek A, de Ruiter K, J van t Veer L, Tollenaar R, van Leeuwen F, Verhoef S, et al.
Eur J Hum Genet
. 2014 Aug;
23(5):588-95.
PMID: 25138101
In this study, we evaluated the diagnostic value of the Dutch Clinical Genetic Center (CGC) referral guidelines for BRCA1/2 mutation testing in 903 early breast cancer patients, unselected for family...
14.
Schoeps A, Rudolph A, Seibold P, Dunning A, Milne R, Bojesen S, et al.
Genet Epidemiol
. 2013 Nov;
38(1):84-93.
PMID: 24248812
Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association analysis. By using methods accounting for gene-environment (G × E) interaction,...
15.
Jamshidi M, Schmidt M, Dork T, Garcia-Closas M, Heikkinen T, Cornelissen S, et al.
Int J Cancer
. 2012 Oct;
132(9):2044-55.
PMID: 23034890
Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect...
16.
Post S, van den Broek A, Rensing B, Pasterkamp G, Goumans M, Doevendans P
J Mol Cell Cardiol
. 2012 Sep;
53(6):899-905.
PMID: 22982114
Peripheral blood mononuclear cells (MNC) enhance cardiac recovery and repair after myocardial infarction (MI). The SDF-1α/CXCR4 axis plays a major role in cell homing to infarcted myocardium and is negatively...
17.
Hilbers F, Boekel N, van den Broek A, van Hien R, Cornelissen S, Aleman B, et al.
Radiother Oncol
. 2011 Nov;
102(1):115-21.
PMID: 22100658
Background And Purpose: It has been established that radiotherapy can increase cardiovascular disease (CVD) risk. Genetic variants, which play a role in the tissue, damage response and angiogenesis regulating TGFβ...
18.
van den Broek A, Broeks A, Horlings H, Canisius S, Braaf L, Langerod A, et al.
Breast Cancer Res Treat
. 2011 Jun;
130(2):599-608.
PMID: 21667122
The tumor suppressor gene TP53 and its regulator MDM2 are both important players in the DNA-damage repair "TP53 response pathway". Common germline polymorphisms in these genes may affect outcome in...
19.
Post S, Smits A, van den Broek A, Sluijter J, Hoefer I, Janssen B, et al.
Cardiovasc Res
. 2009 Sep;
85(3):494-502.
PMID: 19762327
Aims: Mononuclear cells (MNCs) from patients with hereditary haemorrhagic telangiectasia type 1 (HHT1), a genetic disorder caused by mutations in endoglin, show a reduced ability to home to infarcted mouse...