Alexandra H Forst
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Explore the profile of Alexandra H Forst including associated specialties, affiliations and a list of published articles.
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8
Citations
614
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Recent Articles
1.
Ullius A, Luscher-Firzlaff J, Costa I, Walsemann G, Forst A, Gusmao E, et al.
Nucleic Acids Res
. 2014 May;
42(11):6901-20.
PMID: 24782528
The appropriate expression of the roughly 30,000 human genes requires multiple layers of control. The oncoprotein MYC, a transcriptional regulator, contributes to many of the identified control mechanisms, including the...
2.
Feijs K, Forst A, Verheugd P, Luscher B
Nat Rev Mol Cell Biol
. 2013 Jun;
14(7):443-51.
PMID: 23736681
ADP-ribosylation of proteins was first described in the early 1960's, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation...
3.
Verheugd P, Forst A, Milke L, Herzog N, Feijs K, Kremmer E, et al.
Nat Commun
. 2013 Apr;
4:1683.
PMID: 23575687
Adenosine diphosphate-ribosylation is a post-translational modification mediated by intracellular and membrane-associated extracellular enzymes and many bacterial toxins. The intracellular enzymes modify their substrates either by poly-ADP-ribosylation, exemplified by ARTD1/PARP1, or...
4.
Rosenthal F, Feijs K, Frugier E, Bonalli M, Forst A, Imhof R, et al.
Nat Struct Mol Biol
. 2013 Mar;
20(4):502-7.
PMID: 23474714
ADP-ribosylation is an important post-translational protein modification (PTM) that regulates diverse biological processes. ADP-ribosyltransferase diphtheria toxin-like 10 (ARTD10, also known as PARP10) mono-ADP-ribosylates acidic side chains and is one of...
5.
Forst A, Karlberg T, Herzog N, Thorsell A, Gross A, Feijs K, et al.
Structure
. 2013 Mar;
21(3):462-75.
PMID: 23473667
ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD(+) onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as adaptors for distinct protein domains. Other ARTs,...
6.
ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
Feijs K, Kleine H, Braczynski A, Forst A, Herzog N, Verheugd P, et al.
Cell Commun Signal
. 2013 Jan;
11(1):5.
PMID: 23332125
Background: Although ADP-ribosylation has been described five decades ago, only recently a distinction has been made between eukaryotic intracellular poly- and mono-ADP-ribosylating enzymes. Poly-ADP-ribosylation by ARTD1 (formerly PARP1) is best...
7.
Herzog N, Hartkamp J, Verheugd P, Treude F, Forst A, Feijs K, et al.
FEBS J
. 2013 Jan;
280(5):1330-43.
PMID: 23305266
ADP-ribosylation is a post-translational modification that regulates various physiological processes, including DNA damage repair, gene transcription and signal transduction. Intracellular ADP-ribosyltransferases (ARTDs or PARPs) modify their substrates either by poly-...
8.
Kleine H, Herrmann A, Lamark T, Forst A, Verheugd P, Luscher-Firzlaff J, et al.
Cell Commun Signal
. 2012 Sep;
10(1):28.
PMID: 22992334
Unlabelled: Background: ADP-ribosylation is a posttranslational modification catalyzed in cells by ADP-ribosyltransferases (ARTD or PARP enzymes). The ARTD family consists of 17 members. Some ARTDs modify their substrates by adding...