Alexandra Garancher
Overview
Explore the profile of Alexandra Garancher including associated specialties, affiliations and a list of published articles.
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19
Citations
707
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Recent Articles
1.
Borgenvik A, Holmberg K, Bolin S, Zhao M, Savov V, Rosen G, et al.
Cancer Res
. 2022 Oct;
82(24):4586-4603.
PMID: 36219398
Significance: SOX9 facilitates therapy escape and recurrence in medulloblastoma via temporal inhibition of MYC/MYCN genes, revealing a strategy to specifically target SOX9-positive cells to prevent tumor relapse.
2.
Lecoin L, Dempsey B, Garancher A, Bourane S, Ruffault P, Morin-Surun M, et al.
Nat Commun
. 2022 Jun;
13(1):3284.
PMID: 35672398
While apneas are associated with multiple pathological and fatal conditions, the underlying molecular mechanisms remain elusive. We report that a mutated form of the transcription factor Mafa (Mafa) that prevents...
3.
Garancher A, Suzuki H, Haricharan S, Chau L, Masihi M, Rusert J, et al.
Nat Neurosci
. 2021 Dec;
25(1):127.
PMID: 34907396
No abstract available.
4.
Riemondy K, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger A, et al.
Neuro Oncol
. 2021 Jun;
24(2):273-286.
PMID: 34077540
Background: Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease progression. We aimed to determine the influence of neoplastic and immune cell...
5.
Katsushima K, Lee B, Kunhiraman H, Zhong C, Murad R, Yin J, et al.
Neuro Oncol
. 2021 Apr;
23(4):572-585.
PMID: 33844835
Background: Medulloblastoma (MB) is an aggressive brain tumor that predominantly affects children. Recent high-throughput sequencing studies suggest that the noncoding RNA genome, in particular long noncoding RNAs (lncRNAs), contributes to...
6.
Rusert J, Juarez E, Brabetz S, Jensen J, Garancher A, Chau L, et al.
Cancer Res
. 2020 Oct;
80(23):5393-5407.
PMID: 33046443
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and...
7.
Paul M, Huo Y, Liu A, Lesperance J, Garancher A, Wechsler-Reya R, et al.
Neurooncol Adv
. 2020 Jul;
2(1):vdaa062.
PMID: 32642714
Background: Identifying mechanisms of medulloblastoma recurrence is a key to improving patient survival, and targeting treatment-resistant subpopulations within tumors could reduce disease recurrence. Expression of the granulocyte colony-stimulating factor receptor...
8.
Garancher A, Suzuki H, Haricharan S, Chau L, Masihi M, Rusert J, et al.
Nat Neurosci
. 2020 May;
23(7):842-853.
PMID: 32424282
Many immunotherapies act by enhancing the ability of cytotoxic T cells to kill tumor cells. Killing depends on T cell recognition of antigens presented by class I major histocompatibility complex...
9.
Zhu Z, Mesci P, Bernatchez J, Gimple R, Wang X, Schafer S, et al.
Cell Stem Cell
. 2020 Jan;
26(2):187-204.e10.
PMID: 31956038
Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem cells (GSCs). Here we demonstrate...
10.
Cancer M, Hutter S, Holmberg K, Rosen G, Sundstrom A, Tailor J, et al.
Cell Stem Cell
. 2019 Dec;
25(6):855-870.e11.
PMID: 31786016
Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression...