Alexander W Schuppe
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Explore the profile of Alexander W Schuppe including associated specialties, affiliations and a list of published articles.
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17
Citations
99
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Recent Articles
1.
Jiao Z, Jaunich K, Tao T, Gottschall O, Hughes M, Turlik A, et al.
Angew Chem Int Ed Engl
. 2024 Apr;
63(25):e202405779.
PMID: 38619535
Herein, we describe a general hydrodefunctionalization protocol of alcohols and amines through a common isonitrile intermediate. To cleave the relatively inert C-NC bond, we leveraged dual hydrogen atom transfer (HAT)...
2.
Liu Y, Schuppe A, Zhao Y, Lee J, Newhouse T
Tetrahedron Chem
. 2024 Apr;
1.
PMID: 38606284
Degraded limonoids are a subclass of limonoid natural products that derive from ring-intact or ring-rearranged limonoids. Establishment of robust synthetic routes to access them could provide valuable materials to identify...
3.
Schuppe A, Liu Y, Gonzalez-Hurtado E, Zhao Y, Jiang X, Ibarraran S, et al.
Chem
. 2023 Jul;
8(10):2856-2887.
PMID: 37396824
Highly substituted pyridine scaffolds are found in many biologically active natural products and therapeutics. Accordingly, numerous complementary approaches to obtain differentially substituted pyridines have been disclosed. This article delineates the...
4.
Levi Knippel J, Ni A, Schuppe A, Buchwald S
Angew Chem Int Ed Engl
. 2022 Sep;
61(47):e202212630.
PMID: 36137941
α-Stereogenic allyl metalloids are versatile synthetic intermediates which can undergo various stereocontrolled transformations. Most existing methods to prepare α-stereogenic allyl metalloids involve multi-step sequences that curtail the number of compatible...
5.
Losacco G, Bennett R, Haidar Ahmad I, Barrientos R, DaSilva J, Dong Y, et al.
Angew Chem Int Ed Engl
. 2022 Sep;
61(45):e202208854.
PMID: 36111975
Generality in analytical chemistry can be manifested in impactful platforms that can streamline modern organic synthesis and biopharmaceutical processes. We herein introduce a hybrid separation technique named Dual-Gradient Unified Chromatography...
6.
Dong Y, Schuppe A, Mai B, Liu P, Buchwald S
J Am Chem Soc
. 2022 Mar;
144(13):5985-5995.
PMID: 35341240
The selective reductive coupling of vinyl heteroarenes with aldehydes and ketones represents a versatile approach for the rapid construction of enantiomerically enriched secondary and tertiary alcohols, respectively. Herein, we demonstrate...
7.
Hou C, Schuppe A, Levi Knippel J, Ni A, Buchwald S
Org Lett
. 2021 Nov;
23(22):8816-8821.
PMID: 34726414
Conjugated dienes are versatile building blocks and prevalent substructures in synthetic chemistry. Herein, we report a method for the stereoselective hydroalkenylation of alkynes, utilizing readily available enol triflates. We leveraged...
8.
Schuppe A, Levi Knippel J, Borrajo-Calleja G, Buchwald S
J Am Chem Soc
. 2021 Mar;
143(14):5330-5335.
PMID: 33784090
The catalytic enantioselective synthesis of α-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the...
9.
Schuppe A, Liu Y, Newhouse T
Nat Prod Rep
. 2020 Sep;
38(3):510-527.
PMID: 32931541
Covering: 2010 to 2020This review article describes how cationic rearrangement reactions have been used in natural product total synthesis over the last decade as a case study for the many...
10.
Zhang H, Ruiz-Castillo P, Schuppe A, Buchwald S
Org Lett
. 2020 Jun;
22(14):5369-5374.
PMID: 32579375
An improved protocol for the Pd-catalyzed C-O cross-coupling of secondary alcohols is described. The use of biaryl phosphine as the ligand was key to achieving efficient cross-coupling of (hetero)aryl chlorides...