Alexander W Kusnecov
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Explore the profile of Alexander W Kusnecov including associated specialties, affiliations and a list of published articles.
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29
Citations
281
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Recent Articles
1.
Jia N, Ganesan D, Guan H, Jeong Y, Han S, Rajapaksha G, et al.
Autophagy
. 2024 Aug;
21(1):54-79.
PMID: 39171695
Hyperphosphorylation and aggregation of MAPT (microtubule-associated protein tau) is a pathogenic hallmark of tauopathies and a defining feature of Alzheimer disease (AD). Pathological MAPT/tau is targeted by macroautophagy/autophagy for clearance...
2.
Chang N, DaPrano E, Lindman M, Estevez I, Chou T, Evans W, et al.
JCI Insight
. 2024 May;
9(11).
PMID: 38713518
Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. Receptor interacting protein kinase-3 (RIPK3) signaling...
3.
Mitochondrial bioenergetics stimulates autophagy for pathological tau clearance in tauopathy neurons
Jia N, Ganesan D, Guan H, Jeong Y, Han S, Nissenbaum M, et al.
bioRxiv
. 2024 Feb;
PMID: 38405759
Hyperphosphorylation and aggregation of microtubule-associated tau is a pathogenic hallmark of tauopathies and a defining feature of Alzheimer's disease (AD). Pathological tau is targeted by autophagy for clearance, but autophagy...
4.
Chang N, DaPrano E, Evans W, Nissenbaum M, McCourt M, Alzate D, et al.
bioRxiv
. 2023 Aug;
PMID: 37546744
Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. RIPK3 signaling has recently been described...
5.
Jeong Y, Han S, Jia N, Zhang M, Sheshadri P, Tammineni P, et al.
Brain
. 2022 Jan;
145(1):305-323.
PMID: 35022692
Mitochondrial defects are a hallmark of early pathophysiology in Alzheimer's disease, with pathologically phosphorylated tau reported to induce mitochondrial toxicity. Mitophagy constitutes a key pathway in mitochondrial quality control by...
6.
Gifford J, Deshpande P, Mehta P, Wagner G, Kusnecov A
Neuroscience
. 2021 Nov;
481:166-177.
PMID: 34780921
Microglia serve as resident immune cells in the brain, responding to insults and pathological developments. They have also been implicated in shaping synaptic development and regulation. The present study examined...
7.
Gifford J, Norton S, Kusnecov A, Wagner G
Neuroreport
. 2020 Mar;
31(6):433-436.
PMID: 32168103
The gamma-aminobutyric acid (GABA)-shift hypothesis proposes that GABA agonist action is excitatory early in development and transitions to an inhibitory role later in life. In experiment 1, the nonspecific GABA...
8.
Norton S, Gifford J, Pawlak A, Derbaly A, Sherman S, Zhang H, et al.
Neuroscience
. 2020 Mar;
434:8-21.
PMID: 32112916
Valproic acid (VPA) administered to mice during the early postnatal period causes social, cognitive, and motor deficits similar to those observed in humans with autism spectrum disorder (ASD). However, previous...
9.
Glass R, Norton S, Fox N, Kusnecov A
Brain Behav Immun
. 2018 May;
75:12-25.
PMID: 29772261
Stimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the...
10.