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Alexander Schaible

Explore the profile of Alexander Schaible including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 22
Citations 292
Followers 0
Related Specialties
Biomedical Engineering
Biotechnology
Emergency Medicine
Top 10 Co-Authors
Dirk Henrich
Ingo Marzi
Christoph Nau
Katrin Schroder
Caroline Seebach
Jan C Brune
Maren Janko
Maximilian Leiblein
Simon Meier
Rene D Verboket
Published In
Eur J Trauma Emerg Surg
Cells
Materials (Basel)
Tissue Eng Part A
Injury
Affiliations
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Recent Articles
1.
The Impact of Defect Size on Bone Healing in Critical-Size Bone Defects Investigated on a Rat Femur Defect Model Comparing Two Treatment Methods
Kammerer A, Hartmann F, Nau C, Leiblein M, Schaible A, Neijhoft J, et al.
Bioengineering (Basel) . 2024 Mar; 11(3). PMID: 38534561
Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure, human acellular dermis (HAD) has had success...
2.
Pretreatment of Mesenchymal Stem Cells with Electrical Stimulation as a Strategy to Improve Bone Tissue Engineering Outcomes
Bianconi S, Oliveira K, Klein K, Wolf J, Schaible A, Schroder K, et al.
Cells . 2023 Sep; 12(17). PMID: 37681884
Electrical stimulation (EStim), whether used alone or in combination with bone tissue engineering (BTE) approaches, has been shown to promote bone healing. In our previous in vitro studies, mesenchymal stem...
3.
One Stage Masquelets Technique: Evaluation of Different Forms of Membrane Filling with and without Bone Marrow Mononuclear Cells (BMC) in Large Femoral Bone Defects in Rats
Sohling N, Heilani M, Fremdling C, Schaible A, Schroder K, Brune J, et al.
Cells . 2023 May; 12(9). PMID: 37174689
The classic two-stage masquelet technique is an effective procedure for the treatment of large bone defects. Our group recently showed that one surgery could be saved by using a decellularized...
4.
The Induced Membrane Technique-The Filling Matters: Evaluation of Different Forms of Membrane Filling with and without Bone Marrow Mononuclear Cells (BMC) in Large Femoral Bone Defects in Rats
Verboket R, Sohling N, Heilani M, Fremdling C, Schaible A, Schroder K, et al.
Biomedicines . 2022 Mar; 10(3). PMID: 35327444
The Masquelet technique is used to treat large bone defects; it is a two-stage procedure based on an induced membrane. To improve the induced membrane process, demineralized bone matrix in...
5.
Fibrous Demineralized Bone Matrix (DBM) Improves Bone Marrow Mononuclear Cell (BMC)-Supported Bone Healing in Large Femoral Bone Defects in Rats
Verboket R, Irrle T, Busche Y, Schaible A, Schroder K, Brune J, et al.
Cells . 2021 Jun; 10(5). PMID: 34069404
Regeneration of large bone defects is a major objective in trauma surgery. Bone marrow mononuclear cell (BMC)-supported bone healing was shown to be efficient after immobilization on a scaffold. We...
6.
Longitudinal Testing for Respiratory and Gastrointestinal Shedding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Day Care Centers in Hesse, Germany
Hoehl S, Kreutzer E, Schenk B, Westhaus S, Foppa I, Herrmann E, et al.
Clin Infect Dis . 2021 Jan; 73(9):e3036-e3041. PMID: 33388748
Background: With the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ongoing in Europe in June 2020, day care centers were reopened in the state of Hesse, Germany, after...
7.
Impact of scaffold granule size use in Masquelet technique on periosteal reaction: a study in rat femur critical size bone defect model
Leiblein M, Winkenbach A, Koch E, Schaible A, Buchner H, Marzi I, et al.
Eur J Trauma Emerg Surg . 2020 Oct; 48(1):679-687. PMID: 33025170
Purpose: The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. Compared to mature periosteum, the induced membrane differs significantly. However,...
8.
First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat
Sohling N, Leiblein M, Schaible A, Janko M, Schwable J, Seidl C, et al.
Materials (Basel) . 2020 Jul; 13(14). PMID: 32668732
Treatment of large bone defects is one of the great challenges in contemporary orthopedic and traumatic surgery. Grafts are necessary to support bone healing. A well-established allograft is demineralized bone...
9.
Introduction of a New Surgical Method to Improve Bone Healing in a Large Bone Defect by Replacement of the Induced Membrane by a Human Decellularized Dermis Repopulated with Bone Marrow Mononuclear Cells in Rat
Leiblein M, Kolb T, Christian L, Schroder K, Yaman C, Schaible A, et al.
Materials (Basel) . 2020 Jun; 13(11). PMID: 32526914
The Masquelet technique for the treatment of large bone defects is a two-stage procedure based on an induced membrane. We eliminate the first surgical step by using a decellularized dermal...
10.
Determination of the effective dose of bone marrow mononuclear cell therapy for bone healing in vivo
Janko M, Pollinger S, Schaible A, Bellen M, Schroder K, Heilani M, et al.
Eur J Trauma Emerg Surg . 2020 Mar; 46(2):265-276. PMID: 32112259
Introduction: Cell-based therapy by bone marrow mononuclear cells (BMC) in a large-sized bone defect has already shown improved vascularization and new bone formation. First clinical trials are already being conducted....