Alexander P J Vlaar
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Explore the profile of Alexander P J Vlaar including associated specialties, affiliations and a list of published articles.
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235
Citations
3611
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Recent Articles
1.
van Minnen O, Linde M, Oude Lansink-Hartgring A, van den Boogaard B, Bunge J, Delnoij T, et al.
Trials
. 2025 Mar;
26(1):90.
PMID: 40087802
Background: The RATE trial is a three-arm non-inferiority randomized controlled trial in adult patients treated with extracorporeal membrane oxygenation (ECMO) on the effect of anticoagulation levels on mortality, hemorrhagic, and...
2.
Steenvoorden T, de Kruijf K, Appelman B, Moggre B, Bos L, Vlaar A, et al.
Crit Care Explor
. 2025 Mar;
7(3):e1222.
PMID: 40079888
Importance: Sepsis-related host-response anomalies contribute to acute kidney injury (AKI) duration. Data on the host-response specific to COVID-19-associated AKI (COVID-AKI) in critically ill patients is limited. Objectives: We postulated that...
3.
Schaap C, Klanderman R, Peters A, Vlaar A, Muller M
Transfus Med Rev
. 2025 Mar;
39(2):150893.
PMID: 40068327
Anemia is almost universal in critically ill patients, with 25% receiving blood transfusions as clinicians aim to prevent insufficient oxygen delivery. The current 'restrictive' hemoglobin (Hb) threshold of 7 g/dL...
4.
Kho E, van den Dool R, Mahes S, Corsmit O, Vlaar A, Koolbergen D, et al.
Br J Anaesth
. 2025 Mar;
PMID: 40023745
Background: To maintain adequate perfusion, cerebral blood flow (CBF) is preserved by changes in cerebrovascular resistance (CVR) inversely related to fluctuations in mean arterial blood pressure (MAP). It has been...
5.
Rellum S, Noteboom S, van der Ster B, Schuurmans J, Kho E, Vlaar A, et al.
Eur J Anaesthesiol
. 2025 Feb;
PMID: 40012367
Background: The hypotension prediction index (HPI) predicts hypotension, with randomised trials showing a significant reduction in hypotension-related metrics. However, the reliability of previous validation studies is debated, and it's unclear...
6.
Flint A, Poole A, Raasveld S, Bailey M, Brady K, Chen P, et al.
Crit Care Explor
. 2025 Feb;
7(3):e1197.
PMID: 39982126
Importance: Blood transfusions are a common and potentially lifesaving intervention in ICU patients but are associated with harm and often transfused inconsistently with guidelines. However, it is not well known...
7.
van Amstel R, Rademaker E, Kennedy J, Bos L, Peters-Sengers H, Butler J, et al.
Crit Care
. 2025 Feb;
29(1):58.
PMID: 39905513
Background: The application of sepsis subtypes to enhance personalized medicine in critically ill patients is hindered by the lack of validation across diverse cohorts and the absence of a simple...
8.
Noteboom S, Kho E, Veelo D, van der Ster B, van Haeren M, Viersen V, et al.
Anesth Analg
. 2025 Jan;
PMID: 39841608
Background: Rotational thromboelastometry (ROTEM) is widely used for point-of-care coagulation testing to reduce blood transfusions. Accurate interpretation of ROTEM data is crucial and requires substantial training. This study investigates the...
9.
Jian Z, Liu X, Kouz K, Settels J, Davies S, Scheeren T, et al.
Br J Anaesth
. 2025 Jan;
134(2):308-316.
PMID: 39788817
Background: Hypotension is associated with organ injury and death in surgical and critically ill patients. In clinical practice, treating hypotension remains challenging because it can be caused by various underlying...
10.
Noteboom S, Kho E, Galanty M, Sanchez C, Ten Bookum F, Veelo D, et al.
EBioMedicine
. 2024 Dec;
111():105529.
PMID: 39731854
Background: Clinical decision-making is increasingly shifting towards data-driven approaches and requires large databases to develop state-of-the-art algorithms for diagnosing, detecting and predicting diseases. The intensive care unit (ICU), a data-rich...