Alexander O Pasternak
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Explore the profile of Alexander O Pasternak including associated specialties, affiliations and a list of published articles.
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42
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1181
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Recent Articles
11.
Adams P, Berkhout B, Pasternak A
Curr Opin HIV AIDS
. 2022 Aug;
17(5):301-307.
PMID: 35938464
Purpose Of Review: To summarize the current status and highlight recent findings on predictive biomarkers for posttreatment HIV control (PTC) and virological remission. While historically, many studies focused on virological...
12.
Verdikt R, Bendoumou M, Bouchat S, Nestola L, Pasternak A, Darcis G, et al.
EBioMedicine
. 2022 Apr;
79:103985.
PMID: 35429693
Background: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of...
13.
Pasternak A, Berkhout B
Viruses
. 2021 Sep;
13(9).
PMID: 34578332
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure....
14.
Pasternak A, Vroom J, Kootstra N, Wit F, de Bruin M, De Francesco D, et al.
Elife
. 2021 Aug;
10.
PMID: 34387543
Background: It remains unclear whether combination antiretroviral therapy (ART) regimens differ in their ability to fully suppress human immunodeficiency virus (HIV) replication. Here, we report the results of two cross-sectional...
15.
Pinzone M, Weissman S, Pasternak A, Zurakowski R, Migueles S, ODoherty U
JCI Insight
. 2021 Jul;
6(16).
PMID: 34228640
Historically, naive cells have been considered inconsequential to HIV persistence. Here, we compared the contributions of naive and memory cells to the reservoirs of individuals with a spectrum of reservoir...
16.
Cicilionyte A, Berkhout B, Pasternak A
Curr Opin HIV AIDS
. 2021 May;
16(4):223-231.
PMID: 33993171
Purpose Of Review: Despite decades of suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and fuel viral rebound if therapy is interrupted. The persistence of viral reservoirs in infected individuals is...
17.
Pasternak A, Psomas C, Berkhout B
Front Microbiol
. 2021 Mar;
12:648434.
PMID: 33717047
Combination antiretroviral therapy (ART) suppresses human immunodeficiency virus (HIV) replication and improves immune function. However, due to the persistence of long-lived HIV reservoirs, therapy interruption almost inevitably leads to a...
18.
Scherpenisse M, Kootstra N, Bakker M, Berkhout B, Pasternak A
mBio
. 2021 Mar;
12(2).
PMID: 33688002
Incomplete restoration of CD4 T-cell counts on antiretroviral therapy (ART) is a major predictor of HIV-related morbidity and mortality. To understand the possible mechanisms behind this poor immunological response despite...
19.
Darcis G, Berkhout B, Pasternak A
Viruses
. 2020 May;
12(5).
PMID: 32349381
In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong. Persistence...
20.
Pasternak A, Grijsen M, Wit F, Bakker M, Jurriaans S, Prins J, et al.
JCI Insight
. 2020 Feb;
5(6).
PMID: 32097124
Plasma viral load (VL) and CD4+ T cell count are widely used as biomarkers of HIV type 1 (HIV-1) replication, pathogenesis, and response to antiretroviral therapy (ART). However, the clinical...