Alexander M Ishov
Overview
Explore the profile of Alexander M Ishov including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
568
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sarwar S, Morozov V, Newcomb M, Yan B, Brant J, Opavsky R, et al.
Cell Death Dis
. 2024 Aug;
15(8):558.
PMID: 39090086
Prostate cancer (PCa) is the second leading cause of cancer-related death in American men. PCa that relapses after hormonal therapies, referred to as castration resistant PCa (CRPC), often presents with...
2.
Morozov V, Riva A, Sarwar S, Kim W, Li J, Zhou L, et al.
Nucleic Acids Res
. 2023 Aug;
51(19):10194-10217.
PMID: 37638746
Incorporation of histone variant H3.3 comprises active territories of chromatin. Exploring the function of H3.3 in prostate cancer (PC), we found that knockout (KO) of H3.3 chaperone HIRA suppresses PC...
3.
Morozov V, Riva A, Sarwar S, Kim W, Li J, Zhou L, et al.
bioRxiv
. 2023 May;
PMID: 37214820
Key Points: *H3.3 at enhancers promotes acetylation of H3K27Ac and retention of AR/BRD4 complex for transcription regulation*Knockout of H3.3 chaperone HIRA suppresses PC cells growth and deregulates androgen-induced transcription*H3.3/HIRA pathway...
4.
Sarwar S, Morozov V, Purayil H, Daaka Y, Ishov A
Cell Death Dis
. 2022 Oct;
13(10):868.
PMID: 36229449
Androgen ablation therapy is the standard of care for newly diagnosed prostate cancer (PC) patients. PC that relapsed after hormonal therapy, referred to as castration-resistant PC (CRPC), often presents with...
5.
Gurumurthy A, Yu D, Stees J, Chamales P, Gavrilova E, Wassel P, et al.
Nucleic Acids Res
. 2021 Jan;
49(3):1383-1396.
PMID: 33476375
Super-enhancers (SEs) mediate high transcription levels of target genes. Previous studies have shown that SEs recruit transcription complexes and generate enhancer RNAs (eRNAs). We characterized transcription at the human and...
6.
Ishov A, Gurumurthy A, Bungert J
Emerg Top Life Sci
. 2020 Apr;
4(3):281-291.
PMID: 32338276
Genes under control of super-enhancers are expressed at extremely high levels and are frequently associated with nuclear speckles. Recent data suggest that the high concentration of unphosphorylated RNA polymerase II...
7.
Rivera-Rodriguez A, Chiu-Lam A, Morozov V, Ishov A, Rinaldi C
Int J Nanomedicine
. 2018 Sep;
13:4771-4779.
PMID: 30197514
Introduction: Overcoming resistance to antimitotic drugs, such as paclitaxel (PTX), would represent a major advance in breast cancer treatment. PTX induces mitotic block and sensitive cells exit mitosis dying by...
8.
Morozov V, Giovinazzi S, Ishov A
Epigenetics Chromatin
. 2017 Dec;
10(1):63.
PMID: 29273057
Background: The main chromatin unit, the nucleosome, can be modulated by the incorporation of histone variants that, in combination with posttranslational histones modifications, determine epigenetics properties of chromatin. Understanding the...
9.
Morozov V, Li Y, Clowers M, Ishov A
Oncotarget
. 2017 Oct;
8(37):62131-62142.
PMID: 28977932
Androgen receptor (AR) mediates initiation and progression of prostate cancer (PCa); AR-driven transcription is activated by binding of androgens to the ligand-binding domain (LBD) of AR. Androgen ablation therapy offers...
10.
Rapkin L, Ahmed K, Dulev S, Li R, Kimura H, Ishov A, et al.
Epigenetics Chromatin
. 2015 Oct;
8:44.
PMID: 26500702
Background: The death domain-associated protein (DAXX) collaborates with accessory proteins to deposit the histone variant H3.3 into mouse telomeric and pericentromeric repeat DNA. Pericentromeric repeats are the main genetic contributor...