Alexander Lukashev
Overview
Explore the profile of Alexander Lukashev including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
603
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Recent Articles
1.
Gulyaeva K, Nadinskaia M, Maslennikov R, Aleshina Y, Goptar I, Lukashev A, et al.
Sci Rep
. 2025 Mar;
15(1):8394.
PMID: 40069378
Gut dysbiosis plays an important role in cirrhosis, but the mechanism of its development was not established. The aim of the study was to test the hypothesis that portal hypertension...
2.
Aleshina Y, Lukashev A
Virus Evol
. 2025 Feb;
11(1):veaf006.
PMID: 39989717
Astroviruses are a diverse group of small non-enveloped positive sense single-stranded RNA viruses that infect animals and birds. More than half of all known genome sequences of mammalian astroviruses are...
3.
Yudaeva A, Kostyusheva A, Kachanov A, Brezgin S, Ponomareva N, Parodi A, et al.
Cells
. 2024 Nov;
13(22).
PMID: 39594663
Gene therapies hold significant promise for treating previously incurable diseases. A number of gene therapies have already been approved for clinical use. Currently, gene therapies are mostly limited to the...
4.
Brezgin S, Frolova A, Bayurova E, Slatinskaya O, Ponomareva N, Parshina E, et al.
Anal Chem
. 2024 Oct;
96(43):17432-17443.
PMID: 39402710
Extracellular vesicles (EVs), biomimetics, and other biological nanoparticles (BNs) produced from human cells are gaining increasing attention in the fields of molecular diagnostics and nanomedicine for the delivery of therapeutic...
5.
Karandashov I, Kachanov A, Dukich M, Ponomareva N, Brezgin S, Lukashev A, et al.
Viruses
. 2024 Apr;
16(4).
PMID: 38675942
The epitranscriptomic modification mA is a prevalent RNA modification that plays a crucial role in the regulation of various aspects of RNA metabolism. It has been found to be involved...
6.
Kachanov A, Kostyusheva A, Brezgin S, Karandashov I, Ponomareva N, Tikhonov A, et al.
Med Res Rev
. 2024 Mar;
44(5):2112-2193.
PMID: 38549260
Over the past decade, in vivo gene replacement therapy has significantly advanced, resulting in market approval of numerous therapeutics predominantly relying on adeno-associated viral vectors (AAV). While viral vectors have...
7.
Kostyushev D, Brezgin S, Kostyusheva A, Ponomareva N, Bayurova E, Zakirova N, et al.
Mol Ther Nucleic Acids
. 2023 May;
32:478-493.
PMID: 37187708
APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form...
8.
Kostyushev D, Kostyusheva A, Brezgin S, Ponomareva N, Zakirova N, Egorshina A, et al.
Mol Ther Nucleic Acids
. 2023 Mar;
31:482-493.
PMID: 36865089
CRISPR-Cas9 systems can directly target the hepatitis B virus (HBV) major genomic form, covalently closed circular DNA (cccDNA), for decay and demonstrate remarkable anti-HBV activity. Here, we demonstrate that CRISPR-Cas9-mediated...
9.
Brezgin S, Kostyusheva A, Ponomareva N, Bayurova E, Kondrashova A, Frolova A, et al.
Pharmaceutics
. 2023 Feb;
15(2).
PMID: 36839856
Because of their high biocompatibility, biological barrier negotiation, and functionalization properties, biological nanoparticles have been actively investigated for many medical applications. Biological nanoparticles, including natural extracellular vesicles (EVs) and synthetic...
10.
Brezgin S, Parodi A, Kostyusheva A, Ponomareva N, Lukashev A, Sokolova D, et al.
Biotechnol Adv
. 2023 Feb;
64:108122.
PMID: 36813011
Extracellular vesicles (EVs) are cell-derived biological nanoparticles that gained great interest for drug delivery. EVs have numerous advantages compared to synthetic nanoparticles, such as ideal biocompatibility, safety, ability to cross...