Alexander L Dent
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Explore the profile of Alexander L Dent including associated specialties, affiliations and a list of published articles.
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3840
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Recent Articles
1.
Chen Q, Abdi A, Luo W, Yuan X, Dent A
JCI Insight
. 2024 Oct;
9(19).
PMID: 39377224
T follicular regulatory (TFR) cells are found in the germinal center (GC) response and, along with T follicular helper (TFH) cells, help to control the development of high-affinity antibodies (Ab)....
2.
Dent A
Allergol Int
. 2024 Sep;
74(1):20-24.
PMID: 39232918
Allergen-specific IgE is a major mediator of allergic responses and contributes greatly to allergic disease in the human population. Therapies that inhibit the production of IgE would be useful for...
3.
Ke F, Benet Z, Shelyakin P, Britanova O, Gupta N, Dent A, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(5):e2304020121.
PMID: 38261619
Follicular regulatory T cells (Tfr) can play opposite roles in the regulation of germinal center (GC) responses. Depending on the studies, Tfr suppress or support GC and B cell affinity...
4.
Dadelahi A, Abushahba M, Ponzilacqua-Silva B, Chambers C, Moley C, Lacey C, et al.
PLoS Pathog
. 2023 Sep;
19(9):e1011672.
PMID: 37721965
Brucellosis, caused by facultative, intracellular Brucella spp., often results in chronic and/or lifelong infection. Therefore, Brucella must employ mechanisms to subvert adaptive immunity to cause chronic infection. B lymphocytes enhance...
5.
Chen Q, Dent A
J Immunol
. 2023 Jun;
211(1):15-22.
PMID: 37339403
Development of high-affinity Abs in the germinal center (GC) is dependent on a specialized subset of T cells called "T follicular helper" (TFH) cells that help select Ag-specific B cells....
6.
Ke F, Benet Z, Maz M, Liu J, Dent A, Kahlenberg J, et al.
Elife
. 2023 Mar;
12.
PMID: 36862132
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that...
7.
Chen Q, Liu H, Luling N, Reinke J, Dent A
J Immunol
. 2023 Feb;
210(7):905-915.
PMID: 36779803
High-affinity allergen-specific IgE is essential for the severe allergic anaphylaxis response. High-affinity Abs are formed by successive rounds of selection of Ag-specific B cells in the germinal center (GC); however,...
8.
Canaria D, Clare M, Yan B, Campbell C, Ismaio Z, Anderson N, et al.
Front Immunol
. 2022 Nov;
13:1032618.
PMID: 36389679
IL-9-producing CD4 T helper cells, termed Th9 cells, differentiate from naïve precursor cells in response to a combination of cytokine and cell surface receptor signals that are elevated in inflamed...
9.
Chen Q, Dent A
J Allergy Clin Immunol
. 2022 Aug;
150(5):1048-1049.
PMID: 35964780
No abstract available.
10.
Chen Q, Xie M, Liu H, Dent A
Cell Rep
. 2022 Jun;
39(13):110990.
PMID: 35767958
Immunoglobulin E (IgE) responses are a central feature of allergic disease. Using a well-established food-allergy model in mice, we show that two sensitizations with cognate B cell antigen (Ag) and...