Alexander Klotz
Overview
Explore the profile of Alexander Klotz including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
192
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Recent Articles
1.
Santi I, Teixeira R, Manfredi P, Hernandez Gonzalez H, Spiess D, Mas G, et al.
EMBO J
. 2024 Sep;
43(21):5211-5236.
PMID: 39322758
Toxin-antitoxin (TA) systems are widespread in bacteria and implicated in genome stability, virulence, phage defense, and persistence. TA systems have diverse activities and cellular targets, but their physiological roles and...
2.
A genetically encoded biosensor to monitor dynamic changes of c-di-GMP with high temporal resolution
Kaczmarczyk A, van Vliet S, Jakob R, Teixeira R, Scheidat I, Reinders A, et al.
Nat Commun
. 2024 May;
15(1):3920.
PMID: 38724508
Monitoring changes of signaling molecules and metabolites with high temporal resolution is key to understanding dynamic biological systems. Here, we use directed evolution to develop a genetically encoded ratiometric biosensor...
3.
Klotz A, Kaczmarczyk A, Jenal U
Appl Environ Microbiol
. 2023 May;
89(6):e0021123.
PMID: 37199671
Inducible gene expression systems are powerful genetic tools to study bacterial physiology, probing essential and toxic gene functions, gene dosage effects, and overexpression phenotypes. For the opportunistic human pathogen Pseudomonas...
4.
Spat P, Klotz A, Rexroth S, Macek B, Forchhammer K
Mol Cell Proteomics
. 2018 Jun;
17(9):1650-1669.
PMID: 29848780
Cyanobacteria that do not fix atmospheric nitrogen gas survive prolonged periods of nitrogen starvation in a chlorotic, dormant state where cell growth and metabolism are arrested. Upon nutrient availability, these...
5.
Doello S, Klotz A, Makowka A, Gutekunst K, Forchhammer K
Plant Physiol
. 2018 Apr;
177(2):594-603.
PMID: 29703865
Many organisms survive stressful conditions via entry into a dormant state that can be rapidly exited when the stressor disappears; this ability provides a strong selective advantage. In the cyanobacterium...
6.
Klotz A, Forchhammer K
Future Microbiol
. 2017 Jan;
12:101-104.
PMID: 28106464
No abstract available.
7.
Klotz A, Georg J, Bucinska L, Watanabe S, Reimann V, Januszewski W, et al.
Curr Biol
. 2016 Oct;
26(21):2862-2872.
PMID: 27720620
The molecular and physiological mechanisms involved in the transition of microbial cells from a resting state to the active vegetative state are critically relevant for solving problems in fields ranging...
8.
Smith A, Klotz A, Wormstone I
Drug Discov Today
. 2016 Jan;
21(3):510-6.
PMID: 26775751
Cataract was used as a model for the prevalence and economic impact of adverse events during the drug development process. Meta-analysis revealed a reported prevalence of cataract at 12.0% (1.0-43.3%),...
9.
Hauf W, Watzer B, Roos N, Klotz A, Forchhammer K
Appl Environ Microbiol
. 2015 Apr;
81(13):4411-22.
PMID: 25911471
Cyanobacteria are photoautotrophic microorganisms which fix atmospheric carbon dioxide via the Calvin-Benson cycle to produce carbon backbones for primary metabolism. Fixed carbon can also be stored as intracellular glycogen, and...
10.
Klotz A, Reinhold E, Doello S, Forchhammer K
Life (Basel)
. 2015 Mar;
5(1):888-904.
PMID: 25780959
Nitrogen starvation acclimation in non-diazotrophic cyanobacteria is characterized by a process termed chlorosis, where the light harvesting pigments are degraded and the cells gradually tune down photosynthetic and metabolic activities....