Alexander J Clarke
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Explore the profile of Alexander J Clarke including associated specialties, affiliations and a list of published articles.
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15
Citations
548
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Recent Articles
1.
Yazicioglu Y, Marin E, Andrew H, Bentkowska K, Johnstone J, Mitchell R, et al.
Sci Immunol
. 2024 Dec;
9(102):eadl4613.
PMID: 39671468
The rapid proliferation of germinal center (GC) B cells requires metabolic reprogramming to meet energy demands, yet these metabolic processes are poorly understood. By integrating metabolomic and transcriptomic profiling of...
2.
Johnstone J, Yazicioglu Y, Clarke A
Curr Opin Immunol
. 2024 Oct;
91:102484.
PMID: 39357080
B cells experience extreme alterations in their metabolism throughout their life cycle, from naïve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the...
3.
Biniaris-Georgallis S, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, et al.
Nature
. 2024 Aug;
634(8035):952-960.
PMID: 39137897
In systemic lupus erythematosus, loss of immune tolerance, autoantibody production and immune complex deposition are required but not sufficient for organ damage. How inflammatory signals are initiated and amplified in...
4.
Yazicioglu Y, Mitchell R, Clarke A
Semin Cell Dev Biol
. 2024 Apr;
161-162:42-53.
PMID: 38608498
Mitochondria play a multitude of essential roles within mammalian cells, and understanding how they control immunity is an emerging area of study. Lymphocytes, as integral cellular components of the adaptive...
5.
6.
Ogbechi J, Wright H, Balint S, Topping L, Kristina Z, Huang Y, et al.
J Autoimmun
. 2023 May;
138:103031.
PMID: 37229811
The aim of this study was to assess the L-type amino acid transporter-1 (LAT1) as a possible therapeutic target for rheumatoid arthritis (RA). Synovial LAT1 expression in RA was monitored...
7.
Yazicioglu Y, Marin E, Sandhu C, Galiani S, Raza I, Ali M, et al.
Nat Immunol
. 2023 Apr;
24(6):991-1006.
PMID: 37095377
Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are incompletely understood. Here we show that the mitochondria...
8.
Frost J, Wideman S, Preston A, Teh M, Ai Z, Wang L, et al.
Sci Adv
. 2022 Oct;
8(40):eabq5384.
PMID: 36197985
Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response that protects against infections but inhibits erythropoiesis. How hypoferremia influences leukocytogenesis is unclear. Using proteomic data, we predicted...
9.
Raza I, Clarke A
Front Immunol
. 2021 Jun;
12:681105.
PMID: 34163480
B cells are central to the pathogenesis of multiple autoimmune diseases, through antigen presentation, cytokine secretion, and the production of autoantibodies. During development and differentiation, B cells undergo drastic changes...
10.
Roy S, Rizvi Z, Clarke A, Macdonald F, Pandey A, Zaiss D, et al.
Nat Commun
. 2021 Jun;
12(1):3182.
PMID: 34075041
Interleukin 9 (IL-9)-producing helper T (Th9) cells are essential for inducing anti-tumor immunity and inflammation in allergic and autoimmune diseases. Although transcription factors that are essential for Th9 cell differentiation...