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Alexander G Weil

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Articles 164
Citations 1559
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Recent Articles
11.
Andrade A, Annett A, Karimi E, Topouza D, Rezanejad M, Liu Y, et al.
Nat Commun . 2024 Sep; 15(1):7769. PMID: 39237515
Histone H3-mutant gliomas are deadly brain tumors characterized by a dysregulated epigenome and stalled differentiation. In contrast to the extensive datasets available on tumor cells, limited information exists on their...
12.
Obaid S, Guberman G, St-Onge E, Campbell E, Edde M, Lamsam L, et al.
Front Neurol . 2024 Aug; 15:1400601. PMID: 39144703
Introduction: Operculo-insular epilepsy (OIE) is a rare condition amenable to surgery in well-selected cases. Despite the high rate of neurological complications associated with OIE surgery, most postoperative deficits recover fully...
13.
Obaid S, Guillemette A, Lapalme-Remis S, Yang J, Weil A, Bouthillier A
Neurosurg Focus Video . 2024 Jul; 11(1):V15. PMID: 38957415
Surgical management of drug-resistant epilepsy (DRE) in patients with multiple periventricular nodular heterotopias (PVNHs) is challenging. Identifying the location of seizure onset within these complex epileptic networks is difficult, and...
14.
Chen J, Harris W, Wu K, Phillips H, Tseng C, Weil A, et al.
Neurology . 2024 Jun; 103(2):e209330. PMID: 38896816
No abstract available.
15.
Niazi F, Han A, Stamm L, Shlobin N, Korman C, Hoang T, et al.
Front Neurol . 2024 Jun; 15:1403266. PMID: 38863514
Background: Refractory (RSE) and super-refractory status epilepticus (SRSE) are serious neurological conditions requiring aggressive management. Beyond anesthetic agents, there is a lack of evidence guiding management in these patients. This...
16.
Mithani K, Richards O, Ebden M, Malik N, Greuter L, Suresh H, et al.
Neuroimage Clin . 2024 May; 42:103613. PMID: 38714093
Background And Objectives: Gelastic seizures due to hypothalamic hamartomas (HH) are challenging to treat, in part due to an incomplete understanding of seizure propagation pathways. Although magnetic resonance imaging-guided laser...
17.
Goel K, Niazi F, Chen J, Hadjinicolaou A, Keezer M, Gallagher A, et al.
BMJ Open . 2024 Feb; 14(2):e080870. PMID: 38346878
Introduction: Hypothalamic hamartomas (HHs) are deep-seated congenital lesions that typically lead to pharmacoresistant epilepsy and a catastrophic encephalopathic syndrome characterised by severe neuropsychological impairment and decline in quality of life....
18.
Krug B, Hu B, Chen H, Ptack A, Chen X, Gretarsson K, et al.
bioRxiv . 2023 Dec; PMID: 38116029
Highlights: The confinement of H3K27me3 at PRC2 nucleation sites without its spreading correlates with increased 3D chromatin interactions.The H3K27M oncohistone concentrates canonical PRC1 that anchors chromatin loop interactions in gliomas,...
19.
Goel K, Ghadiyaram A, Krishnakumar A, Morden F, Higashihara T, Harris W, et al.
Neurosurgery . 2023 Nov; 94(4):666-678. PMID: 37975663
Background And Objectives: Hemimegalencephaly (HME) is a rare diffuse malformation of cortical development characterized by unihemispheric hypertrophy, drug-resistant epilepsy (DRE), hemiparesis, and developmental delay. Definitive treatment for HME-related DRE is...
20.
Levett J, Elkaim L, Niazi F, Weber M, Iorio-Morin C, Bonizzato M, et al.
Neuromodulation . 2023 Nov; 27(4):597-603. PMID: 37943244
Study Design: Systematic review of the literature. Objectives: In recent years, brain-computer interface (BCI) has emerged as a potential treatment for patients with spinal cord injury (SCI). This is the...