Alexander F Markham
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Explore the profile of Alexander F Markham including associated specialties, affiliations and a list of published articles.
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71
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1838
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Recent Articles
1.
Ingram N, McVeigh L, Abou-Saleh R, Batchelor D, Loadman P, McLaughlan J, et al.
Pharmaceutics
. 2022 Mar;
14(3).
PMID: 35335995
Advanced drug delivery systems, such as ultrasound-mediated drug delivery, show great promise for increasing the therapeutic index. Improvements in delivery by altering the ultrasound parameters have been studied heavily in...
2.
Abou-Saleh R, Delaney A, Ingram N, Batchelor D, Johnson B, Charalambous A, et al.
ACS Appl Bio Mater
. 2022 Jan;
3(11):7840-7848.
PMID: 35019524
Microbubbles (MBs) are widely used as contrast enhancement agents for ultrasound imaging and have the potential to enhance therapeutic delivery to diseases such as cancer. Yet, they are only stable...
3.
Charalambous A, Mico V, McVeigh L, Marston G, Ingram N, Volpato M, et al.
Nanomedicine
. 2021 Apr;
36:102401.
PMID: 33894396
The hydrophobicity of a drug can be a major challenge in its development and prevents the clinical translation of highly potent anti-cancer agents. We have used a lipid-based nanoemulsion termed...
4.
Faluyi O, Hull M, Markham A, Bonifer C, Coletta P
Oncol Lett
. 2021 Mar;
21(4):263.
PMID: 33664826
With its significant contribution to cancer mortality globally, advanced colorectal cancer (CRC) requires new treatment strategies. However, despite recent good results for mismatch repair (MMR)-deficient CRC and other malignancies, such...
5.
Ye S, Azad A, Chambers J, Beckett A, Roach L, Moorcroft S, et al.
Small
. 2020 Oct;
16(46):e2003793.
PMID: 33103323
The generation of effective and safe nanoagents for biological applications requires their physicochemical characteristics to be tunable, and their cellular interactions to be well characterized. Here, the controlled synthesis is...
6.
Ingram N, McVeigh L, Abou-Saleh R, Maynard J, Peyman S, McLaughlan J, et al.
Theranostics
. 2020 Oct;
10(24):10973-10992.
PMID: 33042265
Most cancer patients receive chemotherapy at some stage of their treatment which makes improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large numbers of potent anti-cancer...
7.
Nair A, Ingram N, Verghese E, Wijetunga I, Markham A, Wyatt J, et al.
Cell Oncol (Dordr)
. 2020 May;
43(5):835-845.
PMID: 32468445
Purpose: The current treatment outcomes in cholangiocarcinoma are poor with cure afforded only by surgical extirpation. The efficacy of targeting the tumoural endothelial marker CD105 in cholangiocarcinoma, as a basis...
8.
Ye S, Brown A, Stammers A, Thomson N, Wen J, Roach L, et al.
Adv Sci (Weinh)
. 2019 Nov;
6(21):1900911.
PMID: 31728277
2D metal nanomaterials offer exciting prospects in terms of their properties and functions. However, the ambient aqueous synthesis of atomically-thin, 2D metallic nanomaterials represents a significant challenge. Herein, freestanding and...
9.
Watson C, Camm N, Crinnion L, Clokie S, Robinson R, Adlard J, et al.
Mol Diagn Ther
. 2017 Oct;
21(6):685-692.
PMID: 28986857
Background: Diagnostic genetic testing programmes based on next-generation DNA sequencing have resulted in the accrual of large datasets of targeted raw sequence data. Most diagnostic laboratories process these data through...
10.
Watson C, Camm N, Crinnion L, Antanaviciute A, Adlard J, Markham A, et al.
J Mol Diagn
. 2017 Sep;
19(6):933-940.
PMID: 28867604
Like many clinical diagnostic laboratories, the Yorkshire Regional Genetics Service undertakes routine investigation of cancer-predisposed individuals by high-throughput sequencing of patient DNA that has been target-enriched for genes associated with...