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Alexander Emmer

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Articles 41
Citations 291
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Recent Articles
1.
Ringelstein M, Asseyer S, Lindenblatt G, Fischer K, Pul R, Skuljec J, et al.
Neurology . 2024 Oct; 103(9):e209888. PMID: 39353149
Background And Objectives: Attack prevention is crucial in managing neuromyelitis optica spectrum disorders (NMOSDs). Eculizumab (ECU), an inhibitor of the terminal complement cascade, was highly effective in preventing attacks in...
2.
Schuster J, Dreyhaupt J, Monkemoller K, Dupuis L, Dieterle S, Weishaupt J, et al.
Eur J Neurol . 2024 Jan; 31(4):e16204. PMID: 38240416
Background And Purpose: In 2016, we concluded a randomized controlled trial testing 1 mg rasagiline per day add-on to standard therapy in 252 amyotrophic lateral sclerosis (ALS) patients. This article...
3.
Ruf W, Boros M, Freischmidt A, Brenner D, Grozdanov V, de Meirelles J, et al.
Brain Commun . 2023 May; 5(3):fcad152. PMID: 37223130
Therapy of motoneuron diseases entered a new phase with the use of intrathecal antisense oligonucleotide therapies treating patients with specific gene mutations predominantly in the context of familial amyotrophic lateral...
4.
Wiesenfarth M, Gunther K, Muller K, Witzel S, Weiland U, Mayer K, et al.
Brain Commun . 2023 Apr; 5(2):fcad087. PMID: 37006326
An expansion of the GGGGCC hexanucleotide in the non-coding region of represents the most common cause of familial amyotrophic lateral sclerosis. The objective was to describe and analyse the clinical...
5.
Wieland L, Schwarz T, Engel K, Volkmer I, Kruger A, Tarabuko A, et al.
Cells . 2022 Nov; 11(22). PMID: 36429047
The immune pathogenesis of multiple sclerosis (MS) is thought to be triggered by environmental factors in individuals with an unfavorable genetic predisposition. Epstein-Barr virus (EBV) infection is a major risk...
6.
Mensch A, Cordts I, Scholle L, Joshi P, Kleeberg K, Emmer A, et al.
J Neuromuscul Dis . 2022 Jun; 9(4):533-541. PMID: 35694932
GFPT1-related congenital myasthenic syndrome (CMS) is characterized by progressive limb girdle weakness, and less prominent involvement of facial, bulbar, or respiratory muscles. While tubular aggregates in muscle biopsy are considered...
7.
Meinicke A, Hartig W, Winter K, Puchta J, Mages B, Michalski D, et al.
Biomolecules . 2022 Jan; 12(1). PMID: 35053244
The classic surfactant proteins (SPs) A, B, C, and D were discovered in the lungs, where they contribute to host defense and regulate the alveolar surface tension during breathing. Their...
8.
Schob S, Puchta J, Winter K, Michalski D, Mages B, Martens H, et al.
J Chem Neuroanat . 2021 Oct; 118:102036. PMID: 34626771
Surfactant protein C (SP-C) modulates cerebrospinal fluid (CSF) rheology. During ageing, its declining levels are accompanied by an increased burden of white matter lesions. Pulmonary SP-C intermediates harbouring the BRICHOS-domain...
9.
Wieland L, Engel K, Volkmer I, Kruger A, Posern G, Kornhuber M, et al.
Front Oncol . 2021 May; 11:637522. PMID: 34026614
Neuroblastoma (NB) is the commonest solid tumor outside the central nervous system in infancy and childhood with a unique biological heterogeneity. In patients with advanced, metastasizing neuroblastoma, treatment failure and...
10.
Engel K, Wieland L, Kruger A, Volkmer I, Cynis H, Emmer A, et al.
Front Oncol . 2021 May; 11:637981. PMID: 33996550
Endogenous retroviruses (ERVs) are becoming more and more relevant in cancer research and might be potential targets. The oncogenic potential of human ERVs (HERVs) has been recognized and includes immunosuppression,...