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Alexander E Vinogradov

Explore the profile of Alexander E Vinogradov including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Anatskaya O, Ponomartsev S, Elmuratov A, Vinogradov A
Int J Mol Sci . 2025 Feb; 26(4). PMID: 40004050
Cardiovascular diseases (CVD) are the primary cause of mortality globally. A significant aspect of CVD involves their association with aging and susceptibility to neonatal programming. These factors suggest that adverse...
2.
Vinogradov A, Anatskaya O
Int J Cancer . 2025 Jan; 156(9):1802-1813. PMID: 39888036
Cell dedifferentiation is considered an important hallmark of cancer. The atavistic reversal to a unicellular-like (UC) state is a less widely accepted concept, so far not included in the conventional...
3.
Anatskaya O, Vinogradov A
Int J Mol Sci . 2024 Apr; 25(8). PMID: 38673782
Mesenchymal stem cells (MSC) attract an increasing amount of attention due to their unique therapeutic properties. Yet, MSC can undergo undesirable genetic and epigenetic changes during their propagation in vitro....
4.
Anatskaya O, Runov A, Ponomartsev S, Vonsky M, Elmuratov A, Vinogradov A
Int J Mol Sci . 2023 Apr; 24(8). PMID: 37108224
Many cardiovascular diseases originate from growth retardation, inflammation, and malnutrition during early postnatal development. The nature of this phenomenon is not completely understood. Here we aimed to verify the hypothesis...
5.
Vinogradov A, Anatskaya O
Int J Mol Sci . 2023 Apr; 24(7). PMID: 37047167
Using meta-analyses, we introduce a unicellular attractor (UCA) model integrating essential features of the 'atavistic reversal', 'cancer attractor', 'somatic mutation', 'genome chaos', and 'tissue organization field' theories. The 'atavistic reversal'...
6.
Vinogradov A, Anatskaya O
Biosystems . 2023 Feb; 224:104844. PMID: 36736879
The growth of complexity is an unsolved and underappreciated problem. We consider possible causes of this growth, hypotheses testing, molecular mechanisms, complexity measures, cases of simplification, and significance for biomedicine....
7.
Vinogradov A, Anatskaya O
Int J Mol Sci . 2022 Oct; 23(19). PMID: 36232785
The biogenetic law (recapitulation law) states that ontogenesis recapitulates phylogenesis. However, this law can be distorted by the modification of development. We showed the recapitulation of phylogenesis during the differentiation...
8.
Anatskaya O, Vinogradov A
Int J Mol Sci . 2022 Sep; 23(17). PMID: 36077092
Polyploid cells demonstrate biological plasticity and stress adaptation in evolution; development; and pathologies, including cardiovascular diseases, neurodegeneration, and cancer. The nature of ploidy-related advantages is still not completely understood. Here,...
9.
Anatskaya O, Vinogradov A
Int J Mol Sci . 2022 Apr; 23(7). PMID: 35408902
DNA replication during cell proliferation is 'vertical' copying, which reproduces an initial amount of genetic information. Polyploidy, which results from whole-genome duplication, is a fundamental complement to vertical copying. Both...
10.
Vinogradov A, Anatskaya O
Int J Mol Sci . 2021 Nov; 22(21). PMID: 34769071
The growth of complexity in evolution is a most intriguing phenomenon. Using gene phylostratigraphy, we showed this growth (as reflected in regulatory mechanisms) in the human genome, tracing the path...